WDR45 Antibodies

AND WDR45 ELISA kits, WDR45 Proteins

Many biological assays use antibodies to detect WDR45, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDR45 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDR45 antibodies...

We validate the specificity of these antibodies to WDR45 by testing them on tissues known to express WDR45 positively and negatively. Browse below to find the WDR45 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WDR45 Infographic by Boster Bio

All WDR45 Products

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Specificity

Applications

Price

WDR45 (NM_007075) Human Over-expression Lysate

WDR45 Human Over-expression Lysates NM_001029896

Human

$628
Cat # LS011152
20 µg, 100 µg

Anti-WIPI4/WDR45 antibody

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A07905
100 μl/vial

WDR45 Overview

Facts about WD repeat domain phosphoinositide-interacting protein 4.

WDR45 3D structure. Source: alphafold

WD repeat domain phosphoinositide-interacting protein 4 (WDR45)

Plays an important part in the autophagy pathway, that's the significant intracellular degradation system by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. .

Gene Information

Human
Gene Name:	WDR45
Uniprot:	Q9Y484
Entrez:	11152

Family

Belongs to:

WD repeat SVP1 family

Alternative Names

JM5; WD repeat domain 45; WD repeat domain phosphoinositide-interacting protein 4; WD repeat-containing protein 45; WD45 repeat protein interacting with phosphoinositides 4; WDRX1; WDRXI4; WIPI-4; X-linked 1

Molecular Weight

Mass (kDA):
39.868 kDA

Genomic Context


Human

Location:	Xp11.23
Sequence:	X; NC_000023.11 (49074433..49101121, complement)

Tissue Specificity

Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors.

Subcellular Localizations

Preautophagosomal structure. Cytoplasm. Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy.

Diseases

Hereditary Diseases
Nerve Degeneration
Globus Hystericus
Dystonia Disorders
Secondary Parkinson Disease
Dementia
Developmental Delay (disorder)

Embryonic Mosaic

Pathways

Autophagy

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR45

References

PMID: 15602573 by Proikas-Cezanne T., et al. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.

PMID: 21802374 by Lu Q., et al. The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.