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- Table of Contents
WDR5 Antibodies
AND WDR5 ELISA kits, WDR5 Proteins
Many biological assays use antibodies to detect WDR5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WDR5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WDR5 antibodies...
Designing a Western blot for WDR5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the WDR5 Western Blot GuideWDR5 Infographic by Boster Bio
All WDR5 Products
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WDR5 Overview
Facts about WD repeat-containing protein 5.
WD repeat-containing protein 5 (WDR5)
Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation in'Lys-4'.
As part of the MLL1/MLL complex it is involved in methylation and dimethylation in'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
Gene Information
| Human | |
|---|---|
| Gene Name: | WDR5 |
| Uniprot: | P61964 |
| Entrez: | 11091 |
Family
| Belongs to: |
|---|
| WD repeat WDR5/wds family |
Alternative Names
BIG3; BIG-3; BMP2-induced 3-kb gene protein; SWD3; SWD3, Set1c WD40 repeat protein, homolog; WD repeat domain 5; WD repeat-containing protein 5; WDR5; WD-repeat protein 5
Molecular Weight
Mass (kDA):
36.588 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.2 |
| Sequence: | 9; NC_000009.12 (134135382..134159972) |
Subcellular Localizations
Nucleus.
Diseases
- Leukemia
- Malignant Neoplasms
- Hypertrophy
- Chromosomal Translocation
- Neoplasms
- Multiple Organ Failure
- Pituitary Diseases
- Abnormal Degeneration
- Endocrine Gland Neoplasms
- Fibrolamellar Carcinoma
- Nervousness
- Cell Transformation, Neoplastic
Interacting Proteins
- AKAP8
- Arntl
- ATN1
- CHD8
- FAM199X
- HCFC1
- HIST1H3A
- HSF2
- KANSL1
- KANSL2
Pathways
- Methylation
- Histone Methylation
- Osteoblast Differentiation
- Chondrocyte Differentiation
- Proteolysis
- Histone Modification
- Bone Development
- Histone Lysine Methylation
- Chromatin Remodeling
- Pathogenesis
- Atp-dependent Chromatin Remodeling
- Gene Silencing
- Ossification
PTMs
- Methylation
- Acetylation
- Phosphorylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WDR5
bosterbio.com/bosterbio-gene-info-cards/WDR5
References
PMID: 12670868 by Wysocka J., et al. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1.
PMID: 14992727 by Hughes C.M., et al. Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.