Wolframin Antibodies

AND WFS1 ELISA kits, Wolframin Proteins

Many biological assays use antibodies to detect Wolframin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Wolframin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Wolframin antibodies...

We validate the specificity of these antibodies to Wolframin by testing them on tissues known to express WFS1 positively and negatively. Browse below to find the WFS1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for Wolframin? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the WFS1 Western Blot Guide

WFS1 Infographic by Boster Bio

All WFS1 Products

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Product

Figures

Specificity

Applications

Price

Anti-WFS1 Antibody Picoband®

Western blot analysis of WFS1 using anti-WFS1 antibody (A01326-1)

IHC analysis of WFS1 using anti-WFS1 antibody (A01326-1)

IF analysis of WFS1 using anti-WFS1 antibody (A01326-1)

Human, Monkey

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A01326-1
100 μg/vial

Anti-WFS1 Antibody Picoband®

Western blot analysis of WFS1 using anti-WFS1 antibody (A01326-2)

Human

ELISA, WB

$370
Cat # A01326-2
100 µg/vial

WFS1 (NM_006005) Human Over-expression Lysate

WFS1 Human Over-expression Lysates NM_001145853

Human

$628
Cat # LS007466
20 µg, 100 µg

WFS1 Overview

Facts about Wolframin.

WFS1 3D structure. Source: alphafold

Wolframin (WFS1)

Participates in the regulation of cellular Ca(2+) homeostasis, at least partially, by regulating the filling state of the endoplasmic reticulum Ca(2+) store. .

Gene Information

Human
Gene Name:	WFS1
Uniprot:	O76024
Entrez:	7466

Family

Belongs to:

No superfamily

Alternative Names

DFNA14; DFNA38; DFNA6; DIDMOAD; FLJ51211; WFRS; WFS1; WFSwolframin; Wolfram syndrome 1 (wolframin); Wolframin

Molecular Weight

Mass (kDA):
100.292 kDA

Genomic Context


Human

Location:	4p16.1
Sequence:	4; NC_000004.12 (6260368..6303265)

Tissue Specificity

Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Wolfram Syndrome
Diabetes Mellitus
Optic Atrophy
Atrophy
Complete Hearing Loss
Diabetes Mellitus, Non-insulin-dependent
Sensorineural Hearing Loss (disorder)
Neurodegenerative Disorders
Diabetes Mellitus, Insulin-dependent
Mental Disorders
Bipolar Disorder
Insulin Resistance

Insulin Sensitivity
Mood Disorders
Hereditary Diseases
Endoplasmic Reticulum Stress
Impaired Glucose Tolerance
Obesity
Anxiety Disorders

Interacting Proteins

TERF1

Pathways

Secretion
Insulin Secretion
Pathogenesis
Localization
Cell Death
Cell Cycle
Translation
Glucose Homeostasis
Exocytosis
Ion Homeostasis
Rna Interference
Protein Processing
Programmed Cell Death

Cellular Homeostasis
Brain Development
Platelet Aggregation
Protein Glycosylation
Swimming
Cognition
Cell Proliferation

PTMs

Phosphorylation
Glycosylation

Ubiquitination
Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WFS1

References

PMID: 9817917 by Strom T.M., et al. Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein.

PMID: 9771706 by Inoue H., et al. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram Syndrome).