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- Table of Contents
1 Citations 6 Q&As
Facts about Wnt inhibitory factor 1.
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Human | |
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Gene Name: | WIF1 |
Uniprot: | Q9Y5W5 |
Entrez: | 11197 |
Belongs to: |
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No superfamily |
WIF1; WIF-1; WNT inhibitory factor 1
Mass (kDA):
41.528 kDA
Human | |
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Location: | 12q14.3 |
Sequence: | 12; NC_000012.12 (65050626..65121305, complement) |
Secreted.
If you're looking for the best WIF1 marker, there are several places to find it. Boster Biologicals, a biomarker company, specializes in creating ELISA kit and research antibodies for various applications, including cancer, neuroscience, and inflammation. Most of their products are picogram-level sensitive and can be ordered through their website, www.tebubio.com.
This is the Boster bio that shows his contributions to the world of research. His contributions to the field are numerous and varied. He was the leader of the research team in the LOX lab. He was also responsible to establish the standard for LOX markers. Boster's work is widely used today. You can read the full biography of Boster to learn more.
Wif1 has been implicated recently in many important developmental processes, including tooth morphogenesis and lung development. The exact function and role of Wif1 are still unclear. Recent studies have shown that Wif1 is involved in tooth morphogenesis, anorectal development and lung development. Understanding this protein's role in these processes can help scientists make more informed decisions about its use.
WNT regulation is one potential application of WIF1's marker. This protein regulates the inflammatory response of cardiac cells and is found in non-myeloid cells. This makes WIF1 a promising target in immunomodulatory therapies. However, more research is needed in order to fully understand WIF1's role in cardiovascular disease. Here are the Best Uses of The WIF1 Marker
EGCG and DAC treatments demethylate WIF1 promoter area. Then, the samples were analyzed for the methylation status of 64 CpG islands. The results showed that both treatment methods resulted in concentration-dependent demethylation of WIF1 promoter DNA. After 72-h incubation, the WIF1 promoter was demethylated. The methylation status was determined by Bisulfite genomicDNA sequencing.
The structure and functions of Wif1 are fascinating. Understanding how Wif1 works in vivo will require genetically amenable animal models, such as zebrafish. Although the Wif1 gene has been widely expressed in vertebrates many studies have not focused on its role in zebrafish. However, genetic mutants and transgenes will make it easier to study Wif1 in zebrafish.
Wif1 plays a role in the immune response to stop cancer cells from spreading. For example, prostate cancer cells can invade bone tissue. They can be stopped from spreading by restoring Wif1 expression. Wif1 can also be used to reduce cancer cells' invasiveness and motility. Boster Bio's WIF1 marker, which is a WIF1 gene marker, has many uses.
Olfactomedin family protein interacts with Wif1. The antagonistic interaction between Olfactomedin1 and Wif1 fine-tunes retinal cell axon growth, and modulates Wnt Signaling. It is therefore a great candidate for drug targeting. Wif1 expression has been associated with several diseases including diabetic and neovascular AMD.
Boster Bio created the HSPG2 mark with cancer research at heart. The miR-663 gene directly targets HSPG2 in breast cancer cells. Researchers can monitor treatment effect and identify new treatments using a biosensor. This marker is also highly versatile, so researchers can use it for other purposes as well. Boster Bio sells it.
HSPGs are a group of peptides that play a role in many processes, such as wound healing, angiogenesis and neuronal developmental. They are composed of a protein center and a number HS chains that can be either O- or N-sulfated. The HS chain is a critical component of the molecule and most pathogens interact. The biosynthesis process of HSPGs involves complex processes that are discussed in other chapters.
During synapse formation, the HSPG Dlp and Sdc exert opposing influences on the LAR. Both Sdc & Dlp are present at NMJ, but they compete to gain access. Dlp can bind to LAR more efficiently than Sdc, which suggests that a prebound Sdc/LAR combination can act presynaptically and switch between bouton addition and active zone assembly.
WIF1 expression is present in the developing and mature retinas. Recent research suggests that Wif1 may be an antagonist of Wnt4 and is crucial for the pathophysiology and treatment of diabetic retinopathy (DR) and neovascular AMD. To understand more about Wif1 signaling we need to examine the structure Wif1 protein.
WIF1 has been identified as a target of curcumin, which comes from turmeric. Curcumin interactions might provide neuroprotection by activating Wnt signaling. Boster Bio's article about the WIF1 marker will provide more information. Here are a few examples that the WIF1 marker could be used in zebrafish.
Wif1 has been implicated in many developmental processes, including anorectal and lung development. It also plays a role in tooth morphogenesis and axon extension. The WIF1 marker is best used in the following ways. We hope that this article has helped you gain a better understanding WIF1 signaling, and its role in developmental processes. This important gene's function will enable you to make better decisions, and help you discover how it can benefit your research.
WIF1 expression can also be detected using qPCR. This gene has been implicated for many processes in recent years including lung development, anorectal growth, tooth morphogenesis and anorectal carcinoma. Despite its importance this gene is still expressed in many cancers. We can now identify patients with elevated WIF1 levels using qPCR and improve their chances of beating cancer by using the WIF1 marker.
The melting temperature of the amplicon is required to determine the intensity of a target gene in a QPCR reaction. LDR primers, or fluorescent probes, can be used to control the marker's melting point. These probes are covalently bonded to the template (a fluorescent reagent) during qPCR. This ensures that the reaction products are highly specific.
WIF-1 is depressed activates the Wnt/b–catenin pathway. Wnt signaling pathways promote lung cancer growth. Wnt signaling pathways activation may be a theoretical basis to develop lung cancer treatments. In addition, lung cancer cells that express Wnt signaling may be more susceptible to lymph node metastasis.
This study identified WIF1 genes as potential biomarkers in DDH. WIF1 expression was significantly elevated in DDH patients who had the genotype AA compared to GG patients. This polymorphism may be useful in early detection of DDH. As biomarkers for DDH we also identified WIF1 polymorphisms. Here, we describe a method for RNA extraction using the WIF1 marker.
To determine the expression of WIF1 within tissues, we used a PCR method. We first amplified WIF1's gene in HEK293 and then cloned this using the pcDNA4/HisMax TopO TA Expression kit (Invitrogen). Next, we selected a stable WIF1 expression cell line. For this, we used the control K562 cell line, which was grown in selective media containing zeocin and was labeled K562w.
The WIF1 gene is a marker that inhibits WNT signals and promotes Chondrogenesis. The loss of this gene can lead to rapid cartilage destruction in mice. The association of DDH and WIF1 was examined in the present study. WIF1 may also be associated hip joint development. Higher levels of WIF1 in DDH patients could lead to a change in hip cartilage or macro-morphology. This suggests that WIF1 may be involved in DDH. WIF1's role is still being explored.
PMID: 10201374 by Hsieh J.-C., et al. A new secreted protein that binds to Wnt proteins and inhibits their activities.
PMID: 19188438 by Kwon H.S., et al. Myocilin is a modulator of Wnt signaling.
*More publications can be found for each product on its corresponding product page