WRAP73 Antibodies

AND WRAP73 ELISA kits, WRAP73 Proteins

Many biological assays use antibodies to detect WRAP73, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WRAP73 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WRAP73 antibodies...

We validate the specificity of these antibodies to WRAP73 by testing them on tissues known to express WRAP73 positively and negatively. Browse below to find the WRAP73 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WRAP73 Infographic by Boster Bio

All WRAP73 Products

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WDR8 (WRAP73) (NM_017818) Human Recombinant Protein

Coomassie blue staining of purified WRAP73 protein

$1249
Cat # PROTQ9P2S5
20 µg

WDR8 (WRAP73) (NM_017818) Human Over-expression Lysate

Human

$628
Cat # LS049856
20 µg, 100 µg

WRAP73 Overview

Facts about WD repeat-containing protein WRAP73.

WRAP73 3D structure. Source: alphafold

WD repeat-containing protein WRAP73 (WRAP73)

The SSX2IP:WRAP73 complex is suggested to function as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777).

Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of this CEP97:CCP110 complex from the mother centriole.

Gene Information

Human
Gene Name:	WRAP73
Uniprot:	Q9P2S5
Entrez:	49856

Family

Belongs to:

No superfamily

Alternative Names

FLJ20430; MGC99569; WD repeat domain 8; WD repeat-containing protein 8

Molecular Weight

Mass (kDA):
51.588 kDA

Genomic Context


Human

Location:	1p36.32
Sequence:	1; NC_000001.11 (3630767..3650103, complement)

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Enriched in the proximal end of the mother centriole (PubMed:26545777). During ciliogenesis also associated with the basal body of the adjacent centriole (PubMed:26675238).

Diseases

Neoplasms
Malnutrition
Hereditary Diseases
Down Syndrome
Fracture
Osteoporotic Fractures
Malignant Neoplasms
Hypertrophy
Colorectal Neoplasms

Inflammation
Osteoporosis
Colorectal Cancer
Heterotopic Ossification

Interacting Proteins

SSX2IP
Ssx2ip

Pathways

Endochondral Ossification
Immune Response
Ossification

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WRAP73

References

PMID: 11401440 by Koshizuka Y., et al. Isolation, characterization, and mapping of the mouse and human WDR8 genes, members of a novel WD-repeat gene family.

PMID: 26545777 by Hori A., et al. The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation.