Exportin-7 (XPO7)

Mediates the nuclear export of proteins (cargos) with wide substrate specificity. From the nucleus binds cooperatively to its cargo and into the GTPase Ran in its active GTP-bound form.

Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complicated and hydrolysis of Ran-GTP into Ran-GDP (triggered by RANBP1 and RANGAP1, respectively) trigger release of the cargo in the export receptor.