5'-3' exoribonuclease 2 Antibodies

AND XRN2 ELISA kits, 5'-3' exoribonuclease 2 Proteins

Many biological assays use antibodies to detect 5'-3' exoribonuclease 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with 5'-3' exoribonuclease 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop 5'-3' exoribonuclease 2 antibodies...

We validate the specificity of these antibodies to 5'-3' exoribonuclease 2 by testing them on tissues known to express XRN2 positively and negatively. Browse below to find the XRN2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for 5'-3' exoribonuclease 2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the XRN2 Western Blot Guide

XRN2 Infographic by Boster Bio

All XRN2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-XRN2 Antibody Picoband®

Western blot analysis of XRN2 using anti-XRN2 antibody (A02797-3)

Flow Cytometry analysis of A431 cells using anti-XRN2 antibody (A02797-3)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A02797-3
100 μg/vial

XRN2 (NM_012255) Human Over-expression Lysate

Human

$960
Cat # LS022803
20 µg, 100 µg

XRN2 Overview

Facts about 5'-3' exoribonuclease 2.

XRN2 3D structure. Source: alphafold

5'-3' exoribonuclease 2 (XRN2)

Possesses 5'->3' exoribonuclease activity (By similarity). May promote the conclusion of transcription by RNA polymerase II.

During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment that is then processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment at this protein can promote termination of transcription.

Gene Information

Human
Gene Name:	XRN2
Uniprot:	Q9H0D6
Entrez:	22803

Family

Belongs to:

5'-3' exonuclease family

Alternative Names

5'-3' exoribonuclease 2; Dhm1-like protein (mouse homolog); DHM1-like protein; DHP protein; EC 3.1.13; EC 3.1.13.-

Molecular Weight

Mass (kDA):
108.582 kDA

Genomic Context


Human

Location:	20p11.22
Sequence:	20; NC_000020.11 (21303313..21389825)

Tissue Specificity

Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.

Subcellular Localizations

Nucleus, nucleolus.

Diseases

Malignant Neoplasms
Neoplasms
Physiological Stress
Salivary Gland Neoplasms
Adenocarcinoma
Neoplasm Metastasis
Lung Neoplasms
Neurodegenerative Disorders
Malignant Neoplasm Of Lung
Carcinogenesis
Carcinoma
Leukemia, Myelocytic, Acute

Virus Diseases
Myeloid Leukemia
Adenoid Cystic Carcinoma
Leukemia
Acute Promyelocytic Leukemia
Adenocarcinoma Of Lung (disorder)
Salivary Gland Adenoid Cystic Carcinoma

Interacting Proteins

CDKN2AIPNL

Pathways

Gene Silencing
Rna Processing
Rna Interference
Localization
Termination Of Rna Polymerase Ii Transcription
Mrna Cleavage
Rna Surveillance
Transport
Lateral Root Formation
Nuclear Rna Surveillance
G1 Phase
Dna Methylation
Ribosome Assembly

Sporulation
Defense Response
Methylation
Ribosome Biogenesis
Carbohydrate Export
Posttranscriptional Gene Silencing
Cell Differentiation

PTMs

Cleavage

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/XRN2

References

PMID: 10409438 by Zhang M., et al. Cloning and mapping of the XRN2 gene to human chromosome 20p11.1- p11.2.

PMID: 16147866 by Li J., et al. A novel splice variant of human XRN2 gene is mainly expressed in blood leukocyte.