YTH domain-containing family protein 2 (YTHDF2)

Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and modulates mRNA stability (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and a few non- coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661).

Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs leads to the localization into mRNA decay sites, like processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440). Needed maternally to regulate oocyte maturation: likely acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity).