ZDHHC17 Antibodies

AND ZDHHC17 ELISA kits, ZDHHC17 Proteins

Many biological assays use antibodies to detect ZDHHC17, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZDHHC17 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZDHHC17 antibodies...

We validate the specificity of these antibodies to ZDHHC17 by testing them on tissues known to express ZDHHC17 positively and negatively. Browse below to find the ZDHHC17 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZDHHC17 Infographic by Boster Bio

All ZDHHC17 Products

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Product

Figures

Specificity

Applications

Price

Anti-ZDH17 ZDHHC17 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A08548
100ul

ZDHHC17 (NM_015336) Human Over-expression Lysate

Human

$628
Cat # LS023390
20 µg, 100 µg

ZDHHC17 Overview

Facts about Palmitoyltransferase ZDHHC17.

ZDHHC17 3D structure. Source: alphafold

Palmitoyltransferase ZDHHC17 (ZDHHC17)

Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145).
May be involved in the sorting or targeting of proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793).

May play a role in Mg(2+) transport (PubMed:18794299). .

Gene Information

Human
Gene Name:	ZDHHC17
Uniprot:	Q8IUH5
Entrez:	23390

Family

Belongs to:

DHHC palmitoyltransferase family

Alternative Names

DHHC-17; EC 2.3.1; EC 2.3.1.-; HIP14HIP-14; huntingtin interacting protein 14; huntingtin interacting protein 3; Huntingtin interacting protein H; Huntingtin yeast partner H; Huntingtin-interacting protein 14; Huntingtin-interacting protein 3; Huntingtin-interacting protein H; HYPHHIP-3; KIAA0946HIP3; palmitoyltransferase ZDHHC17; Putative MAPK-activating protein PM11; Putative NF-kappa-B-activating protein 205; Zinc finger DHHC domain-containing protein 17; zinc finger, DHHC domain containing 17; zinc finger, DHHC-type containing 17

Molecular Weight

Mass (kDA):
72.64 kDA

Genomic Context


Human

Location:	12q21.2
Sequence:	12; NC_000012.12 (76764074..76853701)

Tissue Specificity

Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney.

Subcellular Localizations

Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, presynaptic cell membrane; Multi-pass membrane protein. Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.

Diseases

Huntington Disease
Trinucleotide Repeat Expansion
Nervous System Disorder
Neoplasms
Ischemic Stroke
Cell Transformation, Neoplastic
Thrombus
Myeloid Leukemia, Chronic
Diabetes Mellitus
Vascular System Injuries
Cerebrovascular Accident
Neuropathology Disease

Nervousness
Diabetes Mellitus, Insulin-dependent
Thrombosis
Metaplastic Cell Transformation
Brain Injuries, Acute
Brain Injuries

Interacting Proteins

APBB1IP
ARFGAP3
ATF2
CAPN2
DNAJC5

EEF1A1
EIF3E
FEZ2
GOLGA2
GOLPH3L

GPM6A
GSK3A
HTT
IFT57
KLK8

PPP2R5E
RAB39B
SLC9A9
SNAP23
SNAP25

SPRED1
SPRED2
SPRY2
SPRY4
USP32

WASF2

Pathways

Localization
Transport
Protein Palmitoylation
Cell Death
Synaptic Transmission
Secretion
Intracellular Transport
Insulin Secretion
Platelet Activation

Endocytosis
Exocytosis
Platelet Aggregation

PTMs

Palmitoylation

Acylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZDHHC17

References

PMID: 12393793 by Singaraja R.R., et al. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.

PMID: 12761501 by Matsuda A., et al. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.