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Zinc finger protein 57 Antibodies
AND Zfp57 ELISA kits, Zinc finger protein 57 Proteins
Many biological assays use antibodies to detect Zinc finger protein 57, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zinc finger protein 57 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zinc finger protein 57 antibodies...
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Zfp57 Overview
Facts about Zinc finger protein 57.
Zinc finger protein 57 (Zfp57)
Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is limited in a parent of origin-specific way by epigenetic modification of genomic DNA and chromatin, such as DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions.
Required for the establishment of maternal methylation imprints in SNRPN locus. Acts as a transcriptional repressor in Schwann cells.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Zfp57 |
| Uniprot: | Q8C6P8 |
| Entrez: | 22715 |
Family
| Belongs to: |
|---|
| krueppel C2H2-type zinc-finger protein family |
Alternative Names
C6orf40; TNDM1; zfp-57; zinc finger protein 57 homolog (mouse); zinc finger protein 698; ZNF698
Molecular Weight
Mass (kDA):
47.959 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 17 B1|17 |
| Sequence: | 17; |
Tissue Specificity
Expressed in oocytes and in a subset of adult tissues. Expressed at high levels in testis, and at low levels in cerebellum. Present in sciatic nerve and spinal cord (at protein level).
Diseases
- Diabetes Mellitus
- Diabetes Mellitus, Insulin-dependent
- Sclerosis
- Russell-silver Syndrome
- Beckwith-wiedemann Syndrome
- Multiple Sclerosis
- Clinodactyly
- Embryonal Carcinoma
- Macrocephaly
- Carcinoma
- Diseases In Twins
- Hyperglycemia
Pathways
- Methylation
- Dna Methylation
- Demethylation
- Maintenance Of Dna Methylation
- Dna Hypomethylation
- Cell Differentiation
- Dna Demethylation
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Zfp57
bosterbio.com/bosterbio-gene-info-cards/Zfp57
References
PMID: 8120052 by Okazaki S., et al. A novel nuclear protein with zinc fingers down-regulated during early mammalian cell differentiation.
PMID: 15070898 by Alonso M.B., et al. Identification and characterization of ZFP-57, a novel zinc finger transcription factor in the mammalian peripheral nervous system.