Coronavirus: SARS-CoV-2 (COVID-19) Related Research Antibodies & Biomarker Panel

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Overview: These proteins were identified through affinity-purification mass spectrometry (AP-MS)

According to Krogan Laboratory’s recent publication, 332 human proteins have been identified to interact with SARS-CoV-2 proteins.

Affinity-purification mass spectrometry (AP-MS) was performed to detect interacting proteins.

1. Recombinantly expressed coronavirus proteins were transfected into HEK293T cells
2. SARS-CoV-2 proteins were captured by reactive human proteins
3. Mass spectrometry was run to identify the reactive proteins

Some observations about the 332 human proteins can be drawn from their findings:

1. The identified interacting proteins are more highly expressed in lungs than other tissues of the body.
2. The interactions between SARS-CoV-2 and human proteins are associated with various biological processes, such as lipid modification, DNA replication, vesicle trafficking, etc., as well as innate immune pathways like IFN signaling pathway and NF-kB signaling pathway.
3. These proteins are more evolutionarily conserved than the average human protein, which means the human population may have similar versions of these proteins. A pandemic-level virus will usually target highly conserved proteins to spread widely within the human population.
4. Out of the 332 human proteins, 67 human proteins or host factors are potentially druggable.

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