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What's going on with this cell? To learn more, download your Apoptosis Death Receptors & Cellular Apoptosis Pathway Maps by clicking the images below. See related antibodies in recommended products below!

Cellular Apoptosis

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Apoptosis Death Receptors Pathway

Apoptosis (aka programmed cell death) is a cell suicide mechanism that is activated through the mitochondria due to cell stress (intrinsic pathway) or initiated via death receptors that sense extracellular death signals through ligand binding (extrinsic pathway). Death Receptors belong to the tumor necrosis factor (TNF) super family, which include TNFR1, Fas, DR3, TRAILR1, TRAILR2, DR6, EDAR, and NGFR. When death receptors are bound by their corresponding ligands, the receptors’ intracellular death domain (DD) interacts with the signaling adaptor Fas-associated death domain (FADD) through the TNFR-associated death domain (TRADD). FADD also associates with pro-caspase 8 or 10 to form death inducing signalling complexes (DISCs) which invoke downstream signal cascades that lead to apoptosis.

Apoptosis Death Receptors Pathway

Cellular Apoptosis Pathway

Apoptosis that occurs through the intrinsic pathway is induced by injury within the cell. Examples of intracellular stresses include oncogenes, hypoxia, direct DNA damage, growth factor withdrawal, and survival factor deprivation. These intrinsic stresses are detected by p53 which triggers pro-apoptotic Bcl-2 family members that inactivate anti-apoptotic Bcl-2 proteins and cIAPs (cellular Inhibitors of Apoptosis). As a result, destabilization of the mitochondrial membrane occurs due to permeabilization. The damaged mitochondria leaks apoptotic factors, such as SMAC (Second Mitochondria-Derived Activator of Caspase) and Cytochrome c, into the cytosol and sets off the caspase proteolytic cascade which destroys the cell from within, eventually ending with cell death.

Cellular Apoptosis Pathway

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Product Review

Anti-HMOX1 Antibody (PB9212)

Review : "The signal was very strong and clean! Thirty micrograms of whole cell extract of pancreatic tumor cell MIA PaCa-2 were loaded on a 4-12% Bis-Tris gel. The membrane was blotted with 1xPBS + 0.2% Tween-20 + 10% non-fat dry milk. The membrane was incubated with Anti-HMOX1 Antibody (PB9212) at the concentration of 200 ng/ml at room temperature for 3 hours. The membrane was then blotted with HRP-conjugated anti-rabbit secondary antibodies at 4oC overnight. The band was detected using regular ECL with 1 minute exposure. A major band with 32 kD was detected." -Chi Li, MEDICINE, UNIVERSITY OF LOUISVILLE, PROFESSOR

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