Rat IL-6/Interleukin-6 ELISA Kit PicoKine®

IL-6 ELISA kit for Rat

Rat IL-6/Interleukin-6 ELISA Kit PicoKine™ (96 Tests). Quantitate Rat Il6 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 5pg/ml. Cited in 435 publication(s).

Product Info Summary

SKU: EK0412
Size: 96 wells/kit, with removable strips.
Reactive Species: Rat
Application: ELISA
Sample Types: cell culture supernatants, serum and plasma (heparin, EDTA, citrate).

Product Name

Rat IL-6/Interleukin-6 ELISA Kit PicoKine®

View all IL-6 ELISA kits

SKU/Catalog Number

EK0412

Size

96 wells/kit, with removable strips.

*Question: How many samples can I assay/run in this kit?

Description

Rat IL-6/Interleukin-6 ELISA Kit PicoKine™ (96 Tests). Quantitate Rat Il6 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 5pg/ml.

Storage & Handling

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Cite This Product

Rat IL-6/Interleukin-6 ELISA Kit PicoKine® (Boster Biological Technology, Pleasanton CA, USA, Catalog # EK0412)

Clonality of Antibodies

See Datasheet for details

Immunogen

Expression system for standard: E.coli; Immunogen sequence: F25-T211

Sensitivity

<5 pg/ml

Assay Range

62.5 pg/ml - 4,000 pg/ml

Cross Reactivity

There is no detectable cross-reactivity with other relevant proteins.

Reactive Species

EK0412 is reactive to Il6 in Rat samples

Validated Sample Types

cell culture supernatants, serum and plasma (heparin, EDTA, citrate).

Application Guarantee

EK0412 is guaranteed for ELISA in Rat by Boster Guarantee

See how Boster Bio validate our ELISA kits: ELISA Validation Information

Background of IL-6

Interleukin-6 (IL-6) is a protein that in humans is encoded by the IL6 gene. Interleukin-6 (IL-6) is involved not only in the hepatic acute phase response but also in adipose tissue metabolism, lipoprotein lipase activity, and hepatic triglyceride secretion. IL-6 is a pleiotropic cytokine that plays a critical role in bone resorption. IL-6 has been suggested to stimulate the HPA axis during immune activation independent of the input of hypothalamic corticotropin-releasing hormone (CRH). Interleukin-6 (IL-6) is an immunoregulatory cytokine that activates a cell-surface signaling assembly composed of IL-6, the IL-6 alpha-receptor (IL-6Ralpha), and the shared signaling receptor gp130. The standard product used in this kit is recombinant rat IL-6, consisting of 188 amino acids with the molecular mass of 21.8kDa.

Kit Components

Catalog Number Description Quantity
EK0412-CAP Anti-Rat Il6 Pre-coated 96-well strip microplate 1
EK0412-ST Rat Il6 Standard 2 vials, 10 ng/tube
EK0412-DA Rat Il6 Biotinylated antibody (100x) 100ul
AR1103 Avidin-Biotin-Peroxidase Complex (100x) 100ul
AR1106-1 Sample Diluent 30ml
AR1106-2 Antibody Diluent 12ml
AR1106-3 Avidin-Biotin-Peroxidase Diluent 12ml
AR1104 Color Developing Reagent (TMB) 10ml
AR1105 Stop Solution 10ml
AR1106-5 Wash Buffer (25x) 20ml
PLA-SEA Adhesive plate sealers 4

*The kit components are not available for individual purchase.

Materials Required But Not Included In Kit

  • Microplate Reader capable of reading absorbance at 450nm.
  • Automated plate washer (optional).
  • Pipettes and pipette tips capable of precisely dispensing 0.5 µl through 1 ml volumes of aqueous solutions.
  • Multichannel pipettes are recommended for large amount of samples.
  • Deionized or distilled water.
  • 500ml graduated cylinders.
  • Test tubes for dilution.

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Validation Standard Curve O.D. At 450nm

Concentration (pg/ml)062.5125250500100020004000
O.D.0.1830.1900.2640.3520.5300.8111.1401.820

Data Example Images

Recommended Sample Dilution Ratios

According to our internal validation assays using this ELISA kit, to detect IL-6, Dilution ratio of 1:1, concentration in serum is target in serum is below detection limit..

Some articles we found to cite concentrations of IL-6 in samples: 23326132 (Pubmed IDs).

Intra Assay Consistency & Inter Assay Consistency

We measured random samples of Rat IL-6/Interleukin-6 ELISA Kit PicoKine® within the same batch/lot to ensure the consistency of the kits' performances. ELISA intra assay consistency is measured using wells from the same plate/assay kit. ELISA inter assay consistency is measured using wells from different plates from the same batch production/lot.

Intra-Assay PrecisionInter-Assay Precision
Sample123123
n161616242424
Mean (pg/ml)19357915312105641466
Standard deviation9.6535.8990.3211.5540.04109.95
CV (%)5%6.2%5.9%5.5%7.1%7.5%

Reproducibility

We ensure reproducibility by testing three samples with differing concentrations of IL-6 in ELISA kits from four different production batches/lots.

LotsLot 1 (pg/ml)Lot 2 (pg/ml)Lot 3 (pg/ml)Lot 4 (pg/ml)Mean (pg/ml)Standard DeviationCV (%)
Sample 11931921751771848.284.5%
Sample 257963161057759922.523.7%
Sample 31531147013401471145369.764.8%
*number of samples for each test n=16.

Gene/Protein Information For Il6 (Source: Uniprot.Org, NCBI)

Uniprot ID

P20607

Gene ID

24498

Gene Name

Il6

Full Name

Interleukin-6

Weight

24.357kDa

Superfamily

IL-6 superfamily

Alternative Names

B cell stimulatory factor-2; B-cell differentiation factor; BSF2; BSF-2; BSF2CTL differentiation factor; CDF; HGFHSFIFNB2Hybridoma growth factor; IFNB2; IFN-beta-2; IL6; IL-6; IL-6B-cell stimulatory factor 2; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A Il6|ILg6, Ifnb2|interleukin 6|interleukin-6|IL-6|Interleukin 6 (interferon, beta 2)

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on Il6, check out the Il6 Infographic

Il6 infographic

We have 30,000+ of these available, one for each gene! check them out.

In this infographic you will see the following information for Il6: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

EK0412 has been cited in 435 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Salvianolic acid A attenuates early brain injury after subarachnoid hemorrhage in rats by regulating ERK/P38/Nrf2 signaling

Pachymic acid ameliorates sepsis-induced acute kidney injury by suppressing inflammation and activating the Nrf2/HO-1 pathway in rats.

Anti-inflammatory and antioxidant effects of curcumin on acute lung injury in a rodent model of intestinal ischemia reperfusion by inhibiting the pathway of NF-Kb

Effect of early fluid resuscitation on the lung in a rat model of lipopolysaccharide-induced septic shock

Cyanidin‑3‑O‑β‑glucoside protects against pulmonary artery hypertension induced by monocrotaline via the TGF‑β1/p38 MAPK/CREB signaling pathway

Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NF‑κB‑mediated inflammatory response

Protective effects of propofol on experimental neonatal acute lung injury

Allicin attenuates lipopolysaccharide‑induced acute lung injury in neonatal rats via the PI3K/Akt pathway

Activation of the p38 MAPK/NF-κB pathway contributes to doxorubicin-induced inflammation and cytotoxicity in H9c2 cardiac cells

A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis

Propofol attenuates inflammatory damage on neurons following cerebral infarction by inhibiting excessive activation of microglia

Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion

Exogenous H2S protects H9c2 cardiac cells against high glucose-induced injury and inflammation by inhibiting the activation of the NF-κB and IL-1β pathways

YAP1 promotes high glucose‑induced inflammation and extracellular matrix deposition in glomerular mesangial cells by modulating NF‑κB/JMJD3 pathway

Effects of endurance exercise on serum inflammatory cytokine level and kidney structure in a rat diabetes model

miR-130a alleviates neuronal apoptosis and changes in expression of Bcl-2/Bax and caspase-3 in cerebral infarction rats through PTEN/PI3K/Akt signaling pathway

The role of Wnt signaling pathway in atherosclerosis and its relationship with angiogenesis

Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation

Anti-Diabetic Effect of Portulaca oleracea L. Polysaccharideandits Mechanism in Diabetic Rats

Pulmonary Artery Smooth Muscle Cell Senescence Promotes the Proliferation of PASMCs by Paracrine IL-6 in Hypoxia-Induced Pulmonary Hypertension

Renoprotective Effect of the Recombinant Anti-IL-6R Fusion Proteins by Inhibiting JAK2/STAT3 Signaling Pathway in Diabetic Nephropathy

Shenling Baizhu Powder Inhibits RV-SA11-Induced Inflammation and Rotavirus Enteritis via TLR4/MyD88/NF-κB Signaling Pathway

Identification of Active Compounds From Yi Nationality Herbal Formula Wosi Influencing COX-2 and VCAM-1 Signaling

Bufei Yishen Formula Restores Th17/Treg Balance and Attenuates Chronic Obstructive Pulmonary Disease via Activation of the Adenosine 2a Receptor

The Potassium SK Channel Activator NS309 Protects Against Experimental Traumatic Brain Injury Through Anti-Inflammatory and Immunomodulatory Mechanisms

The Effect of STAT3 Signal Pathway Activation on Retinopathy of Prematurity

Andrographolide Alleviates Acute Brain Injury in a Rat Model of Traumatic Brain Injury: Possible Involvement of Inflammatory Signaling

Additive effect of Tadalafil and Simvastatin on monocrotaline-induced pulmonary hypertension rats

Protective effects of Carthamus tinctorius injection on isoprenaline-induced myocardial injury in rats

The effects of neuromuscular facilitation techniques on osteoporosis of hemiplegia limbs and serum leptin level in patients or rats with cerebral infarction

Acremonium terricola culture plays anti-inflammatory and antioxidant roles by modulating MAPK signaling pathways in rats with lipopolysaccharide-induced mastitis

Carbachol alleviates myocardial injury in septic rats through PI3K/AKT signaling pathway.

Effect of dexmedetomidine on kidney injury in sepsis rats through TLR4/MyD88/NF-κB/iNOS signaling pathway.

Effect of sevoflurane on hepatic ischemia-reperfusion injury in rats via JAK2-STAT3 pathway

Effect of miR-21/TLR4/NF-κB pathway on myocardial apoptosis in rats with myocardial ischemia-reperfusion.

Tempol relieves lung injury in a rat model of chronic intermittent hypoxia via suppression of inflammation and oxidative stress

3,5,4′-trimethoxy-trans-stilbene loaded PEG-PE micelles for the treatment of colon cancer

Adaptive in vivo Device for Theranostics of Inflammation by Monitoring of Cytokine Interferon-γ and Its Triggered Aspirin Release

The activation of IL-17 signaling pathway promotes pyroptosis in pneumonia-induced sepsis

Resveratrol protects against early polymicrobial sepsis-induced acute kidney injury through inhibiting endoplasmic reticulum stress-activated NF-κB pathway

Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest

Long non-coding RNA MEG3 promotes fibrosis and inflammatory response in diabetic nephropathy via miR-181a/Egr-1/TLR4 axis

The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study

Propofol pretreatment attenuates lipopolysaccharide-induced acute lung injury in rats by activating the phosphoinositide-3-kinase/Akt pathway

Putative role of ischemic postconditioning in a rat model of limb ischemia and reperfusion: involvement of hypoxia-inducible factor-1α expression

Recombinant HDL (Milano) protects endotoxin-challenged rats from multiple organ injury and dysfunction

The Lipoxin A4 Receptor Agonist BML-111 Alleviates Inflammatory Injury and Oxidative Stress in Spinal Cord Injury

Silencing of TRB3 Ameliorates Diabetic Tubule Interstitial Nephropathy via PI3K/AKT Signaling in Rats

Protective Effects of Cucurbitacin B on Acute Lung Injury Induced by Sepsis in Rats

Combination Therapy with Taurine, Epigallocatechin Gallate and Genistein for Protection against Hepatic Fibrosis Induced by Alcohol in Rats

Inhibition of miR-19a-3p decreases cerebral ischemia/reperfusion injury by targeting IGFBP3 in vivo and in vitro

Endothelial colony-forming cells reduced the lung injury induced by cardiopulmonary bypass in rats

DJ-1 exerts anti-inflammatory effects and regulates NLRX1-TRAF6 via SHP-1 in stroke

Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3

Amelioration of PM 2.5 -induced lung toxicity in rats by nutritional supplementation with fish oil and Vitamin E

Dai-Huang-Fu-Zi-Tang alleviates pulmonary and intestinal injury with severe acute pancreatitis via regulating aquaporins in rats

Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-133a Restrains Myocardial Fibrosis and Epithelial–Mesenchymal Transition in Viral Myocarditis Rats Through Suppressing MAML1

OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-κB signalling pathway in acute ischaemic stroke rats

Pulmonary arterial hypertension induced by a novel method: Twice-intraperitoneal injection of monocrotaline:

Alpha 1-antitrypsin ameliorates ventilator-induced lung injury in rats by inhibiting inflammatory responses and apoptosis:

Effect of curcumin on lung epithelial injury and ferroptosis induced by cigarette smoke:

Renovation of Intestinal Barrier by Polydatin in Experimentally Induced Ulcerative Colitis: Comparative Ultrastructural Study with L-Carnosine

Anti-Inflammatory Effect of Lycopene on Experimental Spinal Cord Ischemia Injury via Cyclooxygenase-2 Suppression

The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke

Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways

Protective Effects of Microrna-22 Against Endothelial Cell Injury by Targeting NLRP3 Through Suppression of the Inflammasome Signaling Pathway in a Rat Model of Coronary Heart Disease

Honokiol Attenuates Oligomeric Amyloid β1-42-Induced Alzheimer’s Disease in Mice Through Attenuating Mitochondrial Apoptosis and Inhibiting the Nuclear Factor Kappa-B Signaling Pathway

Baicalin Attenuates Alcoholic Liver Injury through Modulation of Hepatic Oxidative Stress, Inflammation and Sonic Hedgehog Pathway in Rats

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Acupuncture May Improve the Absorption of Baicalin from the Extracts of Scutellaria baicalensis Georgi in Rats with Pelvic Inflammation

Xingnao Jieyu Decoction Reduces Neuroinflammation through the NF-κB Pathway to Improve Poststroke Depression

Inhibition of PTEN Ameliorates Secondary Hippocampal Injury and Cognitive Deficits after Intracerebral Hemorrhage: Involvement of AKT/FoxO3a/ATG-Mediated Autophagy

Acupuncture Attenuates Inflammation in Microglia of Vascular Dementia Rats by Inhibiting miR-93-Mediated TLR4/MyD88/NF-κB Signaling Pathway

RiPerC Attenuates Cerebral Ischemia Injury through Regulation of miR-98/PIK3IP1/PI3K/AKT Signaling Pathway

Effect of Bletilla striata on the Prevention of Postoperative Peritoneal Adhesions in Abrasion-Induced Rat Model

Effect of Bufei Yishen Granules Combined with Electroacupuncture in Rats with Chronic Obstructive Pulmonary Disease via the Regulation of TLR-4/NF-κB Signaling

Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway

Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats

Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund’s Adjuvant-Induced Arthritis Rats

Inhibitory Effects of Angelica Polysaccharide on Activation of Mast Cells

Changes in the Interstitial Cells of Cajal and Immunity in Chronic Psychological Stress Rats and Therapeutic Effects of Acupuncture at the Zusanli Point (ST36)

Sequential Treatments with Tongsai and Bufei Yishen Granules Reduce Inflammation and Improve Pulmonary Function in Acute Exacerbation-Risk Window of Chronic Obstructive Pulmonary Disease in Rats

Protective Effects of Berberine on Isoproterenol-Induced Acute Myocardial Ischemia in Rats through Regulating HMGB1-TLR4 Axis

Epinephrine Enhances the Response of Macrophages under LPS Stimulation

Role of Wnt/β-catenin pathway agonist SKL2001 in Caerulein-induced acute pancreatitis

Berberine Hydrochloride Prevents Postsurgery Intestinal Adhesion and Inflammation in Rats

Crocetin attenuating Urinary tract Infection and adherence of uropathogenic E. coli in NRK-52E cells via an inflammatory pathway

Attenuation of diabetic cardiomyopathy by relying on kirenol to suppress inflammation in a diabetic rat model

Synovial fibroblast‐targeting liposomes encapsulating an NF‐κB‐blocking peptide ameliorates zymosan‐induced synovial inflammation

2,3,4′,5‐TETRAHYDROXYSTILBENE‐2‐O‐β‐d‐GLUCOSIDE SUPPRESSES MATRIX METALLOPROTEINASE EXPRESSION AND INFLAMMATION IN ATHEROSCLEROTIC RATS

Wnt10a/β-catenin signaling is involved in kindlin-1-mediated astrocyte activation in a chronic construction injury rat model

Flurbiprofen axetil protects against cerebral ischemia/reperfusion injury via regulating miR-30c-5p and SOX9

Berberine ameliorates experimental varicocele‐induced damages at testis and sperm levels; evidences for oxidative stress and inflammation

Resveratrol attenuates hyperoxia‐induced oxidative stress, inflammation and fibrosis and suppresses Wnt/β‐catenin signalling in lungs of neonatal rats

Suberoylanilide Hydroxamic Acid Alleviates Acute Lung Injury Induced by Severe Hemorrhagic Shock and Resuscitation in Rats

Effects of Ghrelin miRNA on Inflammation and Calcium Pathway in Pancreatic Acinar Cells of Acute Pancreatitis

Piperlongumine produces antidepressant-like effects in rats exposed to chronic unpredictable stress

Targeting Smox Is Neuroprotective and Ameliorates Brain Inflammation in Cerebral Ischemia/Reperfusion Rats

Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model

MiR-20a-5p overexpression prevented diabetic cardiomyopathy via inhibition of cardiomyocyte apoptosis, hypertrophy, fibrosis and JNK/NF-κB signalling pathway

Proteomic Analysis of Hydroxysafflor Yellow A Against Cerebral Ischemia/Reperfusion Injury in Rats

Ivabradine protects rats against myocardial infarction through reinforcing autophagy via inhibiting PI3K/AKT/mTOR/p70S6K pathway

Increased levels of angiotensin Ⅱ type 1 receptor autoantibodies in female infertility

Diminution of microRNA-98 alleviates renal fibrosis in diabetic nephropathy by elevating Nedd4L and inactivating TGF-β/Smad2/3 pathway

Novel optimized drug delivery systems for enhancing spinal cord injury repair in rats

Protective effects of salusin-α and salusin-β on renal ischemia/reperfusion damage and their levels in ischemic acute renal failure

Ac2-26 mitigated acute respiratory distress syndrome rats via formyl peptide receptor pathway

Budesonide instillation immediately after reperfusion ameliorates ischemia/reperfusion-induced injury in the transplanted lung of rat

NF-κB 1-induced LINC00665 regulates inflammation and apoptosis of neurons caused by spinal cord injury by targeting miR-34a-5p

Radioprotective activity of glutathione on cognitive ability in X-ray radiated tumor-bearing mice

Dysregulation of miR-192-5p in acute pancreatitis patients with nonalcoholic fatty liver and its functional role in acute pancreatitis progression

FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways

Elevation of USP4 antagonizes oxygen glucose deprivation/reoxygenation-evoked microglia activation and neuroinflammation-mediated neurotoxicity via the TRAF6-NF-κB signaling

Polydatin ameliorates pulmonary fibrosis by suppressing inflammation and the epithelial mesenchymal transition via inhibiting the TGF-β/Smad signaling pathway

A diet with lactosucrose supplementation ameliorates trinitrobenzene sulfonic acid-induced colitis in rats

Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death

GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib

Biomimetic Hybrid Membrane-Coated Xuetongsu Assisted with Laser Irradiation for Efficient Rheumatoid Arthritis Therapy

Mapping the Changes of Glutamate Using Glutamate Chemical Exchange Saturation Transfer (GluCEST) Technique in a Traumatic Brain Injury Model: A Longitudinal Pilot Study

Evaluation of Brain Pharmacokinetic and Neuropharmacodynamic Attributes of an Antiepileptic Drug, Lacosamide, in Hepatic and Renal Impairment: Preclinical Evidence

Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson’s Disease

Comparison of Avidin, Neutravidin, and Streptavidin as Nanocarriers for Efficient siRNA Delivery

Acute Electrical Stimulation of Nucleus Ambiguus Enhances Immune Function in Rats

Adrenomedullin Reduces Secondary Injury and Improves Outcome in Rats with Fluid Percussion Brain Injury

Establishment of rapid risk assessment model for cigarette smoke extract exposure in chronic obstructive pulmonary disease

Protective effect of genistein isolated from Hydrocotyle sibthorpioides on hepatic injury and fibrosis induced by chronic alcohol in rats

ADIOL protects against 3-NP-induced neurotoxicity in rats: Possible impact of its anti-oxidant, anti-inflammatory and anti-apoptotic actions

Effects of environmental stress following myocardial infarction on behavioral measures and heart failure progression: The influence of isolated and group housing conditions

JAX2, an ethanol extract of Hyssopus cuspidatus Boriss, can prevent bronchial asthma by inhibiting MAPK/NF-κB inflammatory signaling

Chronic unpredictable mild stress accelerates lipopolysaccharide- induced microglia activation and damage of dopaminergic neurons in rats

JSH-23 prevents depressive-like behaviors in mice subjected to chronic mild stress: Effects on inflammation and antioxidant defense in the hippocampus

NAMPT inhibitor protects ischemic neuronal injury in rat brain via anti-neuroinflammation

Lipoxin A4 analog attenuates morphine antinociceptive tolerance, withdrawal-induced hyperalgesia, and glial reaction and cytokine expression in the spinal cord of rat

Spinal TRPC6 channels contributes to morphine-induced antinociceptive tolerance and hyperalgesia in rats

Sulfiredoxin-1 protects primary cultured astrocytes from ischemia-induced damage

Effect of crocetin on vascular smooth muscle cells migration induced by advanced glycosylation end products

Garcinol protects against cerebral ischemia-reperfusion injury in vivo and in vitro by inhibiting inflammation and oxidative stress

Punicalagin prevents cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammatory response, and apoptosis in rats

Exosomes from microRNA-145-5p-modified HUCB-MSCs attenuate CCl4-induced hepatic fibrosis via down-regulating FSCN1 expression

Acupuncture attenuates cognitive deficits through α7nAChR mediated anti-inflammatory pathway in chronic cerebral hypoperfusion rats

Sulforaphane mitigates LPS-induced neuroinflammation through modulation of Cezanne/NF-κB signalling

Melatonin therapy protects against renal injury before and after release of bilateral ureteral obstruction in rats

The protective effects of acupoint gel embedding on rats with myocardial ischemia-reperfusion injury

Adenovirus-mediated overexpression of sST2 attenuates cardiac injury in the rat with severe acute pancreatitis

The role of phosphatidylcholine and deoxycholic acid in inflammation

Endothelial progenitor cells attenuate the lung ischemia/reperfusion injury following lung transplantation via the endothelial nitric oxide synthase pathway

Intraintestinal administration of ulinastatin protects against sepsis by relieving intestinal damage

Fish-oil emulsion (omega-3 polyunsaturated fatty acids) attenuates acute lung injury induced by intestinal ischemia–reperfusion through Adenosine 5′-monophosphate-activated protein kinase–sirtuin1 pathway

Protective effect of Astragaloside IV against sepsis-induced acute lung injury in rats

Metabolomics analysis of the therapeutic effects of Qiwei Tongbi oral liquid on rheumatoid arthritis in rats

Effects of fucoidan on gut flora and tumor prevention in 1,2-dimethylhydrazine-induced colorectal carcinogenesis

Formononetin protects TBI rats against neurological lesions and the underlying mechanism

Combined exposure of alumina nanoparticles and chronic stress exacerbates hippocampal neuronal ferroptosis via activating IFN-γ/ASK1/JNK signaling pathway in rats

Flaxseed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats

Schinus terebinthifolius fruits intake ameliorates metabolic disorders, inflammation, oxidative stress, and related vascular dysfunction, in atherogenic diet-induced obese rats. Insight of their chemical characterization using HPLC-ESI-QTOF-MS/MS

Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling

Evaluation of anti-inflammatory potential of the leaves of Wendlandia heynei (Schult.) Santapau & Merchant in Sprague Dawley rat

In vivo anti-inflammatory activity and UPLC-MS/MS profiling of the peels and pulps of Cucumis melo var. cantalupensis and Cucumis melo var. reticulatus

Ilex asprella aqueous extracts exert in vivo anti-inflammatory effects by regulating the NF-κB, JAK2/STAT3, and MAPK signaling pathways

Restoring Th17/Treg balance via modulation of STAT3 and STAT5 activation contributes to the amelioration of chronic obstructive pulmonary disease by Bufei Yishen formula

Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase

Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats

1β-Hydroxyalantolactone from Inulae Flos alleviated the progression of pulmonary fibrosis via inhibiting JNK/FOXO1/NF-κB pathway

Silencing miR-181b-5p upregulates PIAS1 to repress oxidative stress and inflammatory response in rats with alcoholic fatty liver disease through inhibiting PRMT1

The effect of FTY720 at different doses and time-points on LPS-induced acute lung injury in rats

Spinal Ninjurin2 contributes to the neuropathic pain via NF-κB-mediated neuroinflammation in the spared sciatic nerve injury rats

MicroRNA-375-3p in endothelial progenitor cells-derived extracellular vesicles relieves myocardial injury in septic rats via BRD4-mediated PI3K/AKT signaling pathway

Prediction and verification of target of helenalin against hepatic stellate cell activation based on miR-200a-mediated PI3K/Akt and NF-κB pathways

LncRNA-5657 silencing alleviates sepsis-induced lung injury by suppressing the expression of spinster homology protein 2

Protective role of microRNA-27a upregulation and HSP90 silencing against cerebral ischemia-reperfusion injury in rats by activating PI3K/AKT/mTOR signaling pathway

Methyl helicterilate ameliorates alcohol-induced hepatic fibrosis by modulating TGF-β1/Smads pathway and mitochondria-dependent pathway

Methyl helicterte ameliorates liver fibrosis by regulating miR-21-mediated ERK and TGF-β1/Smads pathways

Protective effects of ginsenoside Rg1 on splenocytes and thymocytes in an aging rat model induced by d-galactose

Artesunate ameliorates severe acute pancreatitis (SAP) in rats by inhibiting expression of pro-inflammatory cytokines and Toll-like receptor 4

Knockdown of placental growth factor (PLGF) mitigates hyperoxia-induced acute lung injury in neonatal rats: Suppressive effects on NFκB signaling pathway

Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats

Sinomenine hydrochloride loaded thermosensitive liposomes combined with microwave hyperthermia for the treatment of rheumatoid arthritis

Polysaccharide from Ephedra sinica Stapf inhibits inflammation expression by regulating Factor-β1/Smad2 signaling

Potential role of lycopene in targeting proprotein convertase subtilisin/kexin type-9 to combat hypercholesterolemia

Mitochondrial dysfunction and inflammatory response in the cytotoxicity of NR8383 macrophages induced by fine particulate matter

Protective potential of epigallocatechin-3-gallate against benign prostatic hyperplasia in metabolic syndrome rats

Effect of intravenous immunoglobulin treatment on brain interferon-gamma and interleukin-6 levels in a rat kindling model

Toxicology study for magnetic injection of prednisolone into the rat cochlea

Calcitonin gene-related peptide inhibits the cardiac fibroblasts senescence in cardiac fibrosis via up-regulating klotho expression

The effect of menthol on acute experimental colitis in rats

1,25-Vitamin D3 protects against cooking oil fumes-derived PM2.5-induced cell damage through its anti-inflammatory effects in cardiomyocytes

Protective effects of L-carnitine, N-acetylcysteine and genistein in an experimental model of liver fibrosis

Artesunate ameliorates high glucose-induced rat glomerular mesangial cell injury by suppressing the TLR4/NF-κB/NLRP3 inflammasome pathway

Gastroprotective effect of gamma-aminobutyric acid against ethanol-induced gastric mucosal injury

Intestinal Flora Dysbiosis Aggravates Cognitive Dysfunction Associated With Neuroinflammation in Heart Failure

Hemostatic performance of chitosan-based hydrogel and its study on biodistribution and biodegradability in rats

Study of a new biodegradable hernia patch to repair abdominal wall defect in rats

The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion

Beneficial effects of chlorogenic acid treatment on neuroinflammation after deep hypothermic circulatory arrest may be mediated through CYLD/NF-κB signaling

Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats

Ac2-26 ameliorates lung ischemia-reperfusion injury via the eNOS pathway

GC/MS-based metabonomics approach reveals effects of Xuebijing injection in CLP induced septic rats

Wedelolactone alleviates doxorubicin-induced inflammation and oxidative stress damage of podocytes by IκK/IκB/NF-κB pathway

Xuezhikang improves the outcomes of cardiopulmonary resuscitation in rats by suppressing the inflammation response through TLR4/NF-κB pathway

Zeaxanthin exerts protective effects on acetic acid-induced colitis in rats via modulation of pro-inflammatory cytokines and oxidative stress

Effects of penehyclidine hydrochloride on severe acute pancreatitis-associated acute lung injury in rats

Lycopene amends LPS induced oxidative stress and hypertriglyceridemia via modulating PCSK-9 expression and Apo-CIII mediated lipoprotein lipase activity

Pre-conditioning with tanshinone IIA attenuates the ischemia/reperfusion injury caused by liver grafts via regulation of HMGB1 in rat Kupffer cells

Protective effect of vitamin E against ethanol-induced small intestine damage in rats

Gadd45b is a novel mediator of depression-like behaviors and neuroinflammation after cerebral ischemia

Potassium 2-(1-hydroxypentyl)-benzoate attenuates neuronal apoptosis in neuron–astrocyte co-culture system through neurotrophy and neuroinflammation pathway

Intervention effect and mechanism of curcumin in chronic urinary tract infection in rats

Adaptive in vivo device for theranostics of inflammation: Real-time monitoring of interferon-γ and aspirin

Polycaprolactone/polysialic acid hybrid, multifunctional nanofiber scaffolds for treatment of spinal cord injury

Ortho-vanillin nanoparticle-doped glucan microspheres exacerbate the anti-arthritic effects of methotrexate in adjuvant-induced arthritis in rats

The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury

Early-Life Social Isolation-Induced Depressive-Like Behavior in Rats Results in Microglial Activation and Neuronal Histone Methylation that Are Mitigated by Minocycline

Biochanin A Protects Against Lipopolysaccharide-Induced Damage of Dopaminergic Neurons Both In Vivo and In Vitro via Inhibition of Microglial Activation

Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP+)-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling pathway

Effect of Fluoride on Small Intestine Morphology and Serum Cytokine Contents in Rats

Hypoglycemic mechanism of polysaccharide from Cyclocarya paliurus leaves in type 2 diabetic rats by gut microbiota and host metabolism alteration

The protective effect of Cordycepin on diabetic nephropathy through autophagy induction in vivo and in vitro

Inhibition of ROS-Activated p38MAPK Pathway is Involved in the Protective Effect of H2S Against Chemical Hypoxia-Induced Inflammation in PC12 Cells

Intravenous immunoglobulin is effective in alleviating hepatic ischemia–reperfusion injury: a rat model study

An investigation of the anti-inflammatory effects of gabapentin on acetic acid-induced colitis in rats

Deregulated miR-384 serves as a biomarker in neonatal hypoxic-ischemic encephalopathy and alleviates microglia-mediated neuroinflammation

Safflower yellow attenuates learning and memory deficits in amyloid β-induced Alzheimer’s disease rats by inhibiting neuroglia cell activation and inflammatory signaling pathways

The effect of sodium valproate on acetic acid-induced colitis in rats

Interference with miR-210 Alleviated Renal Injury in Septic Rats by Inhibiting JAK-STAT Pathway

HGF Reduces Disease Severity and Inflammation by Attenuating the NF-κB Signaling in a Rat Model of Pulmonary Artery Hypertension

JNK Inhibitor SP600125 Attenuates Paraquat-Induced Acute Lung Injury: an In Vivo and In Vitro Study

Periodontitis and vascular inflammatory biomarkers: an experimental in vivo study in rats

Matrine attenuates endotoxin-induced acute liver injury after hepatic ischemia/reperfusion in rats

Therapeutic effects of resveratrol in Escherichia coli -induced rat endometritis model

Aquaporin-1 attenuates macrophage-mediated inflammatory responses by inhibiting p38 mitogen-activated protein kinase activation in lipopolysaccharide-induced acute kidney injury

Protective role of Astragaloside IV in chronic glomerulonephritis by activating autophagy through PI3K/AKT/AS160 pathway

Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment immunomodulation in neurotmesis

Preparation, Characterization and Biological Evaluation of Transparent Thin CM-Chitosan/OCMC Films as New Wound Dressings

Effect of microRNA‐27a‐5p on apoptosis and inflammatory response of pancreatic acinar cells in acute pancreatitis by targeting PTEN

The inhibitory effects of Qingchang Wenzhong granule on the interactive network of inflammation, oxidative stress, and apoptosis in rats with dextran sulfate sodium‐induced colitis

Protective effect of ginsenoside Rg3 on lung injury in diabetic rats

Microglial polarization and plasticity: Evidence from organotypic hippocampal slice cultures

Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinsons disease model via activating the aromatic hydrocarbon receptor pathway

Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinsons disease model via activating the aromatic hydrocarbon receptor pathway

Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinsons disease model via activating the aromatic hydrocarbon receptor pathway

Dexmedetomidine Attenuates Neuroinflammatory–Induced Apoptosis after Traumatic Brain Injury via Nrf2 signaling pathway

Multifunctional Supramolecular Hydrogel for Prevention of Epidural Adhesion after Laminectomy
Species: Rat

Chen Q,Lei YQ,Liu JF,Wang ZC,Cao H.Beneficial effects of chlorogenic acid treatment on neuroinflammation after deep hypothermic circulatory arrest may be mediated through CYLD/NF-κB signaling.Brain Res.2021 Jun 30:147572.doi:10.1016/j.brainres.2021.147572.Epub ahead of print.PMID:34216581.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:BRAIN TISSUE, DILUTION:NA

Yan Jiang,Li Zhao,Qing Chen,Lihong Zhou,"Exploring the Mechanism of Berberine Intervention in Ulcerative Colitis from the Perspective of Inflammation and Immunity Based on Systemic Pharmacology",Evidence-Based Complementary and Alternative Medicine,vol.2021,Article ID 9970240,11 pages,2021.https://doi.org/ 10.1155/2021/9970240
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Li Q,Jin Y,Ye X,Wang W,Deng G,Zhang X.Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-133a Restrains Myocardial Fibrosis and Epithelial-Mesenchymal Transition in Viral Myocarditis Rats Through Suppressing MAML1.Nanoscale Res Lett.2021 Jul 2;16(1):111.doi:10.1186/s11671-021-03559-2.PMID:34215939.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Wang Y,Chen S,Tan J,Gao Y,Yan H,Liu Y,Yi S,Xiao Z,Wu H.Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinson‘s disease model via activating the aromatic hydrocarbon receptor pathway.Brain Behav.2021 Jun 9.doi:10.1002/brb3.2226.Epub ahead of print.PMID:34105899.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Lipopolysaccharides,I.C.I.B.B.,Fesal,M.,Seif,F.,Abdella,A.,& Amin,H.M.Middle East Journal of Applied Sciences Volume:11| Issue: 01|Jan.-March| 2021.
Species: Rat
EK0412 usage in article: APP: ELISA, SAMPLE:LIVER TISSUE, DILUTION:NA

Ming Tang,Xia Gao,Ting Geng,Xialin Chen,Jiajia Wang,Canjie Shen,Huifang Gao,Mengyu Qian,Zhenzhong Wang,Liang Cao,Wei Xiao,Metabolomics analysis of the therapeutic effects of Qiwei Tongbi oral liquid on rheumatoid arthritis in rats,Journal of Pharmaceutical and Biomedical Analysis, Volume 202,2021,114166,ISSN 0731-7085,https://doi.org/10.1016/j.jpba.2021.114166.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Effect of α-Tocopherol on Cytokines Production, Oxidative Stress, and Liver Injury Induced by Lipopolysaccharides in Male Albino Rats. Amin,H. M.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Cheng Wang,Liang Xian,Shaorui Zheng et al.Cranial Venous Outflow Obstruction Promotes Neuroinflammation And Edema Via ADAM17/solTNF-α/NF-κB Pathway In A Rat Subdural Hematoma Model,11 May 2021,PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-487715/v1]
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:BRAIN TISSUE, DILUTION: NA

Motavallian A,Bouzari S,Zamani E,Karimian P,Dabirian S,Molavi M,Torshkooh FA.An investigation of the anti-inflammatory effects of gabapentin on acetic acid-induced colitis in rats.Mol Biol Rep.2021 Apr 29.doi:10.1007/s11033-021-06357-2.Epub ahead of print.PMID:33928442.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:COLON TISSUE, DILUTION:NA

Xu H,Wang Y,Luo Y.OTULIN is a new target of EA treatment in the alleviation of brain injury and glial cell activation via suppression of the NF-κB signalling pathway in acute ischaemic stroke rats.Mol Med.2021 Apr 9;27(1):37.doi:10.1186/s10020-021-00297-0.PMID:33836646;PMCID:PMC8035756.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:BRAIN TISSUE, DILUTION:NA

Lixin Xia,Shuo Wang,Zhiwen Jiang,Jinhua Chi,Shuqin Yu,Hongjian Li,Yijie Zhang,Lihua Li,Changren Zhou,Wanshun Liu,Baoqin Han,Hemostatic performance of chitosan-based hydrogel and its study on biodistribution and biodegradability in rats,Carbohydrate Polymers,2021,117965,ISSN 0144-8617,https://doi.org/10. 1016/j.carbpol.2021.117965.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE: SERUM, DILUTION:NA

Abukhalil MH, Althunibat OY, Aladaileh SH, Al-Amarat W, Obeidat HM, Al-Khawalde AAA, Hussein OE, Alfwuaires MA, Algefare AI, Alanazi KM, Al-Swailmi FK, Arab HH, Mahmoud AM. Galangin attenuates diabetic cardiomyopathy through modulating oxidative stress, inflammation and apoptosis in rats. Biomed Pharmacother. 2021 Mar 19:111410. doi: 10.1016/j.biopha.2021.111410. Epub ahead of print. PMID: 33752930.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:HEART TISSUE, DILUTION:NA

Zhang P,Gan Z,Tang L,Zhou L,Huang X,Wang J.Exosomes from microRNA-145-5p-modified HUCB-MSCs attenuate CCl4-induced hepatic fibrosis via down-regulating FSCN1 expression.Life Sci.2021 Mar 29:119404.doi:10.1016/j.lfs.2021.119404.Epub ahead of print.PMID:33794251.
Species: Human,Rat

Yin Q,Du T,Yang C,Li X,Zhao Z,Liu R,Yang B,Liu B.Gadd45b is a novel mediator of depression-like behaviors and neuroinflammation after cerebral ischemia.Biochem Biophys Res Commun.2021 Mar 27;554:107-113.doi:10.1016/j.bbrc.2021.03.104.Epub ahead of print.PMID:33784505.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:HIPPOCAMPUS TISSUE, DILUTION:NA

Ouyang, S.,Chen, W.,Gaofeng, Z.,Changcheng, L.,Guoping, T.,Minyan, Z. ... Luo, J. (2021). Cyanidin‑3‑O‑β‑glucoside protects against pulmonary artery hypertension induced by monocrotaline via the TGF‑β1/p38 MAPK/CREB signaling pathway. Molecular Medicine Reports,23, 338.https://doi.org/10.3892/mmr.2021.11977
Species: Human,Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Xiaoling Zhou,Xingwei Xiang,Yufang Zhou,Tianyi Zhou,Shanggui Deng,Bin Zheng,Pingan Zheng,Protective effects of Antarctic krill oil in dextran sulfate sodium-induced ulcerative colitis mice,Journal of Functional Foods,Volume 79,2021,104394,ISSN 1756-4646,h
Species: Mouse
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Martins Ekor,Phyllis E. Owusu Agyei,Ernest Obese,Robert P. Biney,Isaac T. Henneh,Meshack Antwi-Adjei,Ewura S. Yahaya,Gordon Amoakohene,Patrick K. Akakpo bioRxiv 2021.02.15.431245;doi:https://doi.org/10.1101/2021.02.15.431245
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

He C,Su C,Zhang W,Zhou Q,Shen X,Yang J,Shi N.Modulatory Potential of LncRNA Zfas1 for Inflammation and Neuronal Apoptosis in Temporal Lobe Epilepsy.Yonsei Med J.2021 Mar;62(3):215-223.doi:10.3349/ymj.2021.62.3.215.PMID:33635011.
Species: Human,Rat
EK0412 usage in article: APP:ELISA, SAMPLE:NEURON, DILUTION:NA

Jia Q,Zhang H,Su Y,Liu X,Bai J,Lang W,Shi Q,Feng M.Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model.J Physiol Biochem.2021 Feb 17.doi:10.1007/s13105-021-00796-y.Epub ahead of print.PMID:33595775.
Species: Human,Mouse,Rat
EK0412 usage in article: APP:ELISA, SAMPLE:COLON TISSUE, DILUTION:NA

Hongbei Xu,You Wang,Yong Luo et al. OTULIN is a New Target for EA Treatment in Alleviating Brain Injury and The Activation of Glial Cells By Depressing NF-κB Signalling Pathway in Acute Ischaemic Stroke Rats,28 January 2021,PREPRINT (Version 1) available
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:BRAIN TISSUE, DILUTION:NA

The maternal western diet exacerbates the inflammatory response in the offspring, but does not alter the action of the non-steroidal antiinflammatory drug. Nathalia Caroline de Oliveira Melo,Nathália Cavalcanti de Morais Araújo,Alexandra Rabello Freire,Maria Bernadete de Souza Maia,Elizabeth do Nascimento
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SKIN TISSUE, DILUTION:NA

Li J,Xie Y,Zhao P,Qin Y,Oliver BG,Tian Y,Li S,Wang M,Liu X. A chinese herbal formula ameliorates COPD by inhibiting the inflammatory response via downregulation of p65, JNK, and p38. Phytomedicine. 2021 Jan 20;83:153475.doi:10.1016/j.phymed.2021.153475.Ep
Species: Human,Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM AND BALF, DILUTION:NA

Haiyang Zhang,Wenjing Jiao,Hailin Cui,Qinghong Sun,Honggang Fan,Combined exposure of alumina nanoparticles and chronic stress exacerbates hippocampal neuronal ferroptosis via activating IFN-γ/ASK1/JNK signaling pathway in rats,Journal of Hazardous Materia
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:HIPPOCAMPUS, DILUTION:NA

Manman Zhao,Junling Gao,Changmeng Cui,Yanan Zhang,Xiaohua Jiang,Jianzhong Cui, "Inhibition of PTEN Ameliorates Secondary Hippocampal Injury and Cognitive Deficits after Intracerebral Hemorrhage: Involvement of AKT/FoxO3a/ATG-Mediated Autophagy",Oxidative
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:HIPPOCAMPUL TISSUE, DILUTION:NA

Chen T,Liu WB,Qian X,Xie KL,Wang YH.The AMPAR antagonist perampanel protects the neurovascular unit against traumatic injury via regulating Sirt3.CNS Neurosci Ther.2021 Jan 9.doi:10.1111/cns.13580.Epub ahead of print.PMID:33421349.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Liu Yuan,Luo Pei,Zhang Ji-Zhong,Chen Xiao-Yi,Li Li-Min,Wu You-Jiao,Yin Qiao-Zhi,Huang Li.Identification of Active Compounds From Yi Nationality Herbal Formula Wosi Influencing COX-2 and VCAM-1 Signaling. Frontiers in Pharmacology,11.2020.1690.https://www.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Jiang,Guoyong and Lei,AItong and Chen,Yi and Yu,Qiang and Xie,Jianhua and Yang,Ying and Yuan,Tongji and Su, Dan", "Protective effects of Ganoderma atrum polysaccharide against acrylamide-induced inflam mation and oxidative damage in rats","Food Funct.","2
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Yingchao Kang, Yaping Sun, Tiantian Li, Zelin Ren,Garcinol protects against cerebral ischemia-reperfusion injury in vivo and in vitro by inhibiting inflammation and oxidative stress, Molecular and Cellular Probes ,2020, 101672,ISSN 0890-8508,https://doi.o
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:BRAIN TISSUE AND PC12 CELLS, DILUTION:NA

Wang,Q.,Liu,S.,& Han,Z.(2020).miR-339-3p regulated acute pancreatitis induced by caerulein through targeting TNF receptor-associated factor 3 in AR42J cells, Open Life Sciences , 15(1), 912-922. doi:https://doi.org/10.1515/biol-2020-0084.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:MACROPHAGE, DILUTION:NA

Zhang K,Liu R,Gao Y,Ma W,Shen W.Electroacupuncture Relieves LPS-Induced Depression-Like Behaviour in Rats Through IDO-Mediated Tryptophan-Degrading Pathway.Neuropsychiatr Dis Treat.2020 Oct 5;16:2257-2266.doi:10.2147/NDT.S274778.PMID:33116524;PMCID:PMC754
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:HIPPOCAMPUS AND SERUM, DILUTION:NA

Li J,Ma J,Tian Y,Zhao P,Liu X,Dong H,Zheng W,Feng S,Zhang L,Wu M,Zhu L,Liu S,Zhao D.Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signa
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM AND BALF, DILUTION:NA

Wang Y,Zhang L,Li L,Hu H,Pan P,Zhang B,Ning W,Zhao M,Wang S.Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg.Evid Based Complement Alternat Med.2020 Jul 7;2020:5375981.doi:10.1155/2020/5375981.PMID:
Species: Rat

Liu Y,Zhang X,Yan D,Wang Y,Wang N,Liu Y,Tan A,Chen X,Yan H.Chronic acrylamide exposure induced glia cell activation, NLRP3 infl-ammasome upregulation and cognitive impairment.Toxicol Appl Pharmacol.2020 Apr 15;393:114949.doi:10.1016/j.taap.2020.114949.Epu
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SERUM, DILUTION:NA

Liu L,Zhou J,Wang Y,Qi T,Wang Z,Chen L,Suo N.Imatinib inhibits oxidative stress response in spinal cord injury rats by activating Nrf2/HO-1 signaling pathway.Exp Ther Med.2020 Jan;19(1):597-602.doi:10.3892/etm.2019.8270.Epub 2019 Dec 2.PMID:31897102;PMCID
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:SPINAL CORD TISSUE, DILUTION:NA

Feriani A,Tir M,Arafah M,Gómez-Caravaca AM,Contreras MDM,Nahdi S,Taamalli A,Allagui MS,Alwasel S,Segura-Carretero A,Harrath AH,Tlili N. Schinus terebinthifolius fruits intake ameliorates metabolic disorders, inflammation, oxidative stress, and related vas
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:PLASMA, DILUTION:NA

Mao H,Huang Q,Liu Y. MEG3 aggravates hypoxia/reoxygenation induced apoptosis of renal tubular epithelial cells via the miR-129-5p/HMGB1 axis. J Biochem Mol Toxicol.2020 Nov 11:e22649.doi:10.1002 /jbt .22 649. Epub ahead of print.PMID:33175458.
Species: Human,Rat

Liu S, Wang Y, Lu S, Hu J, Zeng X, Liu W, Wang Y, Wang Z. Sacubitril/valsartan treatment relieved the progression of established pulmonary hypertension in rat model and its mechanism. Life Sci. 2020 Dec 10:118877. doi: 10.1016/j.lfs.2020.118877. Epub ahea
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:BLOOD, DILUTION:NA

Zheng X,Cai X,Ye F,Li Y,Wang Q,Zuo Z,Huang W,Wang Z. Perioperative Dexmedetomidine attenuates brain ischemia reperfusion injury possibly via up-regulation of astrocyte Connexin 43. BMC Anesthesiol. 2020 Dec 7;20(1):299.doi: 10.1186/s12871-020-01211-7.PMID
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:BRAIN TISSUE, DILUTION:NA

Wang Q, Xu GX, Tai QH, Wang Y. Lipoxin A4 Reduces Ventilator-Induced Lung Injury in Rats with Large-Volume Mechanical Ventilation. Mediators Inflamm. 2020 Nov 22;2020:6705985. doi: 10.1155/2020/6705985. PMID: 33299377; PMCID: PMC7704204.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:BALF, DILUTION:NA

Cao Y, Wang L, Lin LT, Wang XR, Ma SM, Yang NN, Fan H, Fisher M, Yang JW. Acupuncture attenuates cognitive deficits through α7nAChR mediated anti-inflammatory pathway in chronic cerebral hypoperfusion rats. Life Sci. 2020 Nov 5:118732. doi: 10.1016/j.lfs.
Species: Rat
EK0412 usage in article: APP:ELISA, SAMPLE:HIPPOCAMPUS, DILUTION:NA

Zhang, B., Guo, Z., Lai, S., & Chen, H. (2020). Interference with miR-210 Alleviated Renal Injury in Septic Rats by Inhibiting JAK-STAT Pathway. Inflammation, 1-10.

Toxicology study for magnetic injection of prednisolone into the rat cochlea.

The effects of Jiao-Tai-Wan on sleep, inflammation and insulin resistance in obesity-resistant rats with chronic partial sleep deprivation

Pachymic acid ameliorates sepsis-induced acute kidney injury by suppressing inflammation and activating the Nrf2/HO-1 pathway in rats

The Effects of Resveratrol on Inflammation and Oxidative Stress in a Rat Model of Chronic Obstructive Pulmonary Disease

Novel therapeutic approach by nicotine in experimental model of multiple sclerosis

Sialic acid-modified solid lipid nanoparticles as vascular endothelium-targeting carriers for ischemia-reperfusion-induced acute renal injury

Levels of serum pentraxin 3, IL-6, fetuin A and insulin in patients with rheumatoid arthritis

Changes in mediators of inflammation and pro-thrombosis after 12 months of dietary modification in adults with metabolic syndrome

Effect of fermented camel milk on glucose metabolism, insulin resistance, and inflammatory biomarkers of adolescents with metabolic syndrome: A double-blind, randomized, crossover trial

Dendrobium Officinale Kimura et Migo Ameliorates Insulin Resistance in Rats with Diabetic Nephropathy

Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-?B pathway dependent of HDAC3

THE IMPACT OF THE USE OF SYMBIOTICS IN THE PROGRESSION OF NONALCOHOLIC FATTY LIVER DISEASE IN A RAT MODEL

Ilomastat, a synthetic inhibitor of MMPs, prevents lung injury induced by ?-ray irradiation in mice

Potassium 2-(1-hydroxypentyl)-benzoate attenuates neuronal apoptosis in neuron?astrocyte co-culture system through neurotrophy and neuroinflammation pathway

Resveratrol protects against early polymicrobial sepsis-induced acute kidney injury through inhibiting endoplasmic reticulum stress-activated NF-?B pathway

Protective Effects of Cucurbitacin B on Acute Lung Injury Induced by Sepsis in Rats

Protective effect of geraniol inhibits inflammatory response, oxidative stress and apoptosis in traumatic injury of the spinal cord through modulation of NF-?B and p38 MAPK

Investigation of the Effects and Mechanisms of Mai Tong Formula on Lower Limb Macroangiopathy in a Spontaneous Diabetic Rat Model

Changes in the Interstitial Cells of Cajal and Immunity in Chronic Psychological Stress Rats and Therapeutic Effects of Acupuncture at the Zusanli Point (ST36)

Sequential Treatments with Tongsai and Bufei Yishen Granules Reduce Inflammation and Improve Pulmonary Function in Acute Exacerbation-Risk Window of Chronic Obstructive Pulmonary Disease in Rats

Anti-Diabetic Effect of Portulaca oleracea L Polysaccharideandits Mechanism in Diabetic Rats

Protective effect of Astragaloside IV against sepsis-induced acute lung injury in rats

Expression of scavenger receptor A in rat's liver tissue during acute obstructive cholangitis and its significance

Inhibitory Effects of Angelica Polysaccharide on Activation of Mast Cells

Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP(+))-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling pathway

GEN-27, a Newly Synthetic Isoflavonoid, Inhibits the Proliferation of Colon Cancer Cells in Inflammation Microenvironment by Suppressing NF-?B Pathway

Extracts of Bauhinia championii (Benth) Benth attenuate the in?ammatory response in a rat model of collagen-induced arthritis

Laboratory environment and bio-medical experience: the impact of administration technique on the quality of immune-behavior data results in stress experience

Wound healing treatment by high frequency ultrasound, microcurrent, and combined therapy modifies the immune response in rats

Decrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats

Propofol pretreatment attenuates lipopolysaccharide-induced acute lung injury in rats by activating the phosphoinositide-3-kinase/Akt pathway

TNF?-Mediated Loss of ?-Catenin/E-Cadherin Association and Subsequent Increase in Cell Migration Is Partially Restored by NKX3.1 Expression in Prostate Cells

Epinephrine Enhances the Response of Macrophages under LPS Stimulation

Treatment of acute lung injury by targeting MG53-mediated cell membrane repair

Inhibition of ROS-Activated p38MAPK Pathway is Involved in the Protective Effect of H2S Against Chemical Hypoxia-Induced Inflammation in PC12 Cells

Comparison of Anti-Inflammatory and Anti-Nociceptive Activities of Curcuma Wenyujin Y.H. Chen et C. Ling and Scutellaria Baicalensis Georgi

Whether Co-Administration of Garlic has Negative Influence on Scutellaria Baicalensis Georgi in Treating Models Rats with Pelvic Inflammation?

Yang S, Zhang J, Wang S, Zhao X, Shi J. Oncotarget. 2017 Aug 24;8(53):91185-91198. doi: 10.18632/oncotarget.20434. eCollection 2017 Oct 31. SOCS2 overexpression alleviates diabetic nephropathy in rats by inhibiting the TLR4/NF-κB pathway

Gao D, Jing S, Zhang Q, Wu G. Exp Ther Med. 2018 Jan;15(1):1029-1035. doi: 10.3892/etm.2017.5479. Epub 2017 Nov 10. Pterostilbene protects against acute renal ischemia reperfusion injury and inhibits oxidative stress, inducible nitric oxide syntha...

Li J, Hu SB, Wang LY, Zhang X, Zhou X, Yang B, Li JH, Xiong J, Liu N, Li Y, Wu YZ, Zheng QC. Oncogene. 2017 Nov 30;36(48):6725-6737. doi: 10.1038/onc.2017.272. Epub 2017 Aug 7. Autophagy-dependent generation of Axin2+ cancer stem-like cells promot...

Duan X, Lu L, Wang Y, Zhang F, Mao J, Cao M, Lin B, Zhang X, Shuai X, Shen J. Int J Nanomedicine. 2017 Sep 8;12:6705-6719. doi: 10.2147/IJN.S146742. eCollection 2017. The long-term fate of mesenchymal stem cells labeled with magnetic resonance ima...

Chen C, Chen W, Li Y, Dong Y, Teng X, Nong Z, Pan X, Lv L, Gao Y, Wu G. Oncotarget. 2017 Dec 4;8(67):111522-111534. doi: 10.18632/oncotarget.22869. eCollection 2017 Dec 19. Hyperbaric oxygen protects against myocardial reperfusion injury via the i...

Gu X, Zheng C, Zheng Q, Chen S, Li W, Shang Z, Zhang H. Am J Transl Res. 2017 Dec 15;9(12):5643-5652. eCollection 2017. Salvianolic acid A attenuates early brain injury after subarachnoid hemorrhage in rats by regulating ERK/P38/Nrf2 signaling.

Liao N, Zheng Y, Xie H, Zhao B, Zeng Y, Liu X, Liu J. Stem Cell Res Ther. 2017 Dec 19;8(1):286. doi: 10.1186/s13287-017-0743-7. Adipose tissue-derived stem cells ameliorate hyperglycemia, insulin resistance and liver fibrosis in the type 2 diabeti...

Chen X, Chen C, Fan S, Wu S, Yang F, Fang Z, Fu H, Li Y. J Neuroinflammation. 2018 Apr 20;15(1):116. doi: 10.1186/s12974-018-1151-3. Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization throu...

Zabihi M, Hajhashemi V, Talebi A, Minaiyan M. EXCLI J. 2017 Mar 30;16:414-425. doi: 10.17179/excli2016-727. eCollection 2017. Evaluation of central and peripheral effects of doxepin on acetic acid-induced colitis in rat and the involved mechanisms

Piao X, Liu B, Guo L, Meng F, Gao L. Oxid Med Cell Longev. 2017;2017:7085709. doi: 10.1155/2017/7085709. Epub 2017 Jun 21. Picroside II Shows Protective Functions for Severe Acute Pancreatitis in Rats by Preventing NF-κB-Dependent Autophagy

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10 Customer Q&As for Rat IL-6/Interleukin-6 ELISA Kit PicoKine®

Question

Q: which procedure should I follow in order to thaw whole blood sample for IL-6 ELISA after freezing?

Verified Customer

Verified customer

Asked: 2020-05-10

Answer

A: we do not recommend freezing and thaw whole blood. erythrocytes are fragile and, if frozen and thawed, will undergo hemolysis rendering the samples useless. To keep your blood samples to test IL-6 for a later time, you should let the blood clot in glass tubes and collect the serum to freeze for later use.

Boster Scientific Support

Answered: 2020-05-10

Question

I would like to know more about Rat IL-6 ELISA Kit antibody. Could this be used also as neutralizing antibody? As it stated in the product notes that this antibody can be used to block IL-6/IL-6R interactions. You think it is just the same as neutralizing antibody?

Verified Customer

Verified customer

Asked: 2020-03-19

Answer

The Rat IL-6 ELISA Kit antibody can be used to prevent IL-6 binding to its receptor, therefore it could be used in a neutralizing type of assay.

Boster Scientific Support

Answered: 2020-03-19

Question

To Technical Support: I would like to inquire if this Rat IL-6 ELISA Kit can be used for urine samples?

Verified Customer

Verified customer

Asked: 2020-01-08

Answer

The Rat IL-6 ELISA Kit has been successfully tested with urine samples, we can guarantee that it will worked well. However, we would recommend to start a minimal dilution (such as 2-fold) since based on our experience cytokine levels are often very low in urine. Here

Boster Scientific Support

Answered: 2020-01-08

Question

Q: how to analyze ELISA data? I measured IL-6 level in plasma.

W. Carter

Verified customer

Asked: 2019-11-09

Answer

A: please read this article on ELISA data analysis. bosterbio.com/ELISA-data-analysis-instructions. we also provide a convenient online tool that you can use to analyze ELISA data. bosterbio.com/biology-research-tools/ELISA-data-analysis-online

Boster Scientific Support

Answered: 2019-11-09

Question

Is the Rat IL-6 PicoKine

Verified Customer

Verified customer

Asked: 2019-06-04

Answer

We haven't tested

Boster Scientific Support

Answered: 2019-06-04

Question

Q: can I use citrate plasma as samples in Rat IL-6 Picokine® ELISA Kit (Catalog # EK0412)?

Verified Customer

Verified customer

Asked: 2019-03-18

Answer

A: Chelating agents such as EDTA, Heparin and Citrate can irreversibly bind metal ions from the functional domain of IL-6 causing degradation of its protein structure. IL-6 may be denatured as a result and may compromise the assay's measurements. The chilating sites could also be too close to the epitopes required for detection and block the antigen antibody reaction. We have tested the IL-6 ELISA, treating samples with various anticoagulants and decided that heparin, EDTA or citrate can be used for treatment of blood/plasma samples. Do not use other anticoagulents when collecting samples.

Boster Scientific Support

Answered: 2019-03-18

Question

Q: how many samples can be assayed in a Picokine® ELISA Kit?

Verified Customer

Verified customer

Asked: 2019-02-25

Answer

A: The Picokine® ELISA Kits will generally run a 7-point standard curve, non-specific binding wells, and 39 samples in duplicate. this may might differ by kit so please refer to each datasheet for details.

Boster Scientific Support

Answered: 2019-02-25

Question

Can EK0412 be used with cytosolic fractions?

Verified customer

Asked: 2019-02-08

Answer

We haven't tested tissue lysates/cytosolic fractions with Rat IL-6 ELISA Kit PicoKine EK0412. Endogenous biotin in tissue homogenates might introduce false positive signal. We recommend to run a pilot test to confirm the effect of endogeous biotin first. Add tissue homogenates into the wells then add ABC and TMB without adding any biotinylated detection antibody to see if any signal will be observed. If no signal is produced, proceed and work on the tissue sample by using the kit.

Boster Scientific Support

Answered: 2019-02-08

Question

Q: how are cell lysates prepared for use in Picokine® ELISA kits?

Verified Customer

Verified customer

Asked: 2018-11-16

Answer

A: in those Picokine® ELISAs where cell or tissue lysate is a validated sample type, sample preparation instructions for lysate are included in the product insert. Components in lysate and lysis buffer can have an affect on immunoreactivity, so if lysate is not a validated sample type, care must be taken in sample preparation and validation.

Boster Scientific Support

Answered: 2018-11-16

Question

Q: What is the optimal O.D. value for IL-6 ELISA kit? I performed your IL-6 ELISA on serum samples. For my positive control, I received an O.D. value of 0.826, while my negative control received a value of 0.136. I obtained both of these controls from the ELISA kit, where your kit's typical data shows O.D. values much higher than my positive control and your background is lower. My samples O.D. values are around 0.225 and the highest is only 0.357. can I consider these samples contain IL-6 even though the O.D. values are not very high?

Verified Customer

Verified customer

Asked: 2015-04-07

Answer

A: The absolute O.D. values may change according to incubation time. The more you incubate the higher the O.D. values are going to be. a point of focus should be is whether your sample O.D. values are statistically significantly higher than your blank values. regarding your protocol, you could extend your development time in the substrate incubation step to obtain higher O.D. values, as long as your negative controls' O.D. values are not increasing faster in relation to your positive controls. normally, a sample with O.D. value 2 standard deviations higher than your negative controls can be considered positive. We calculate the sensitivity of this ELISA kit by converting cutoff O.D. value, calculated as the average of 20 negative controls plus 2 standard deviations of the 20 negative controls, into a concentration. in other words, when we claim this IL-6 ELISA kit to have sensitivity of 5pg/ml, that means the minimum amount of IL-6 that can be declared/interpreted as positive by the above standard is 5pg/ml.

Boster Scientific Support

Answered: 2015-04-07

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