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Product Info Summary
| SKU: | R00609 |
|---|---|
| Size: | 100μg/vial |
| Origin Species: | Human |
| Source: | E. coli His12-Met200 |
Product info
Product Name
Recombinant Human CNTF Protein
View all CNTF recombinant proteins
SKU/Catalog Number
R00609
Size
100μg/vial
Description
Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor β subunit, and a CNTF specific α receptor subunit. Upon binding to the CNTF, the β subunit of the CNTF receptorwill undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons. Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE.
Storage & Handling
Lyophilized recombinant human Ciliary Neurotrophic Factor (rhCNTF)remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhCNTF remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Cite This Product
Recombinant Human CNTF Protein (Boster Biological Technology, Pleasanton CA, USA, Catalog # R00609)
Form
Lyophilized
Formulation
Lyophilized after extensive dialysis against PBS.
Purity
>95%, by SDS-PAGE quantitative densitometry by Coomassie® Blue Staining.
Predicted MW
22.9 kDa
Endotoxin
Less than 1 EU/μg of rhCNTF as determined by LAL method.
Amino Acid Sequence
HRRDL CSRSI WLARK IRSDL TALTE SYVKH QGLNK NINLD SADGM PVAST DQWSE LTEAE RLQEN LQAYR TFHVL LARLL EDQQV HFTPT EGDFH QAIHT LLLQV AAFAY QIEEL MILLE YKIPR NEADG MPINV GDGGL FEKKL WGLKV LQELS QWTVR SIHDL RFISS HQTGI PARGS HYIAN NKKM
Assay dilution & Images
Validation Images & Assay Conditions
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Boster Kit Box
Specific Publications For Recombinant Human CNTF Protein (R00609)
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