- Table of Content
Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, produced in Human plasma and having a molecular mass of 725 kDa.
|Size:||200ug, 1mg, 10mg|
|Form:||Sterile Filtered White lyophilized (freeze-dried) powder.|
Alpha-2 Macroglobulin is a serine proteases inhibitor, which inhibits coagulation by inactivating thrombin and Kallikrein, it inhibits fibrinolysis by inactivating plasmin and involved in transport. Alpha-2-Macroglobulin is a large plasma protein, which is produced by the liver, it’s composed of 4 identical subunits bound together by -S-S- bonds. A2M is able to inactivate many kinds of proteinases (including serine-, cysteine-, aspartic- and metalloproteinases). A2M has a 35 amino acid "bait" region in its structure. Proteinases bind and cleave the “bait” region become bound to A2M. Macrophage receptors recognize the proteinase-A2M complex and clear it from the system. A2M binds to and removes MMP-2 and MMP-9 (active forms of the gelatinase) from the circulation using scavenger receptors on the phagocytes. The levels of Alpha-2-macroglobulin are increased in nephrotic syndrome which is a condition where the kidneys start to leak out some of the smaller blood proteins. Due to its large size, A2-macroglobulin is retained in the bloodstream. Increased production of all proteins causes A2-macroglobulin concentration to increase. Chronic renal failure might lead to amyloid by alpha-2-macroglobulin. A2M is raised in cirrhosis, pregnancy and diabetes.
|Product Name||A2M Macroglobulin Alpha-2 Human protein
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|Storage & Handling||Lyophilized A2M protein although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution and filter sterilization A2M can be stored at 4°C for up to 4 weeks. For long term storage and more diluted solutions it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.|
|Description||Human Alpha-2 Macroglobulin is a tetrameric glycoprotein, produced in Human plasma and having a molecular mass of 725 kDa.|
|Alternative Names||A2M; alpha 2Macroglobulin; alpha 2-Macroglobulin; alpha-2-M; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; CPAMD5DKFZp779B086; FWP007; S863-7|
|Cite This Product||A2M Macroglobulin Alpha-2 Human protein (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTP01023)|
|Pack Size||200ug, 1mg, 10mg|
|Form||Sterile Filtered White lyophilized (freeze-dried) powder.|
|Purity||Greater than 96.0%.|
|Formulation||Lyophilized from 0.02M TRIS, 0.15M NaCl and 0.1M Sucrose, pH 8.0.|
|NCBI Gene Id||2|
|Species Of This Entry||Human|
|Superfamily||protease inhibitor I39 (alpha-2-macroglobulin) family|
|Alternative Names||alpha 2-Macroglobulin|A2M; alpha 2Macroglobulin; alpha 2-Macroglobulin; alpha-2-M; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; CPAMD5DKFZp779B086; FWP007; S863-7|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
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