Anti-Aak1 Antibody

AAK1 antibody

Boster Bio Anti-Aak1 Antibody (Catalog # A05368). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: A05368
Size: 0.1 mg
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: ELISA, WB

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Product Name

Anti-Aak1 Antibody

View all AAK1 Antibodies

SKU/Catalog Number

A05368

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Aak1 Antibody (Catalog # A05368). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Aak1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Aak1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05368)

Host

Rabbit

Contents

Aak1 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Aak1 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of the human Aak1. The immunogen is located within amino acids 830 - 880 of Aak1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A05368 is reactive to AAK1 in Human, Mouse, Rat

Applications

A05368 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

103.885kDa

Background of AAK1

AP2-associated protein kinase 1 (Aak1) is a member of the Ark1/Prk1 subfamily of Ser/Thr protein kinases that are thought to regulate endocytosis by phosphorylating the accessory endocytic components. Aak1 interacts with and phosphorylates the mu2 subunit of the AP-2 complex, which promotes binding of the AP-2 to tyrosine based (Yxxphi) internalization motif-containing receptors and subsequent receptor endocytosis. At least two isoforms of Aak1 are known to exist; the longer isoform contains an extended carboxy-terminus that contains an additional clathrin-binding domain. Overexpression of this long isoform or Aak1 depletion by RNA interference impairs transferrin recycling from the early/sorting endosome, suggesting that Aak1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its recycling back to the plasma membrane.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Aak1 antibody can be used for detection of Aak1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For AAK1 (Source: Uniprot.org, NCBI)

Gene Name

AAK1

Full Name

AP2-associated protein kinase 1

Weight

103.885kDa

Superfamily

protein kinase superfamily

Alternative Names

AAK1; Adaptor-associated kinase 1; AP2 associated kinase 1; AP2-associated protein kinase 1; DKFZp686F03202; DKFZp686K16132; EC 2.7.11.1; FLJ23712; FLJ25931; FLJ31060; FLJ45252; KIAA1048FLJ42882; MGC138170; MGC164568; MGC164570 AAK1 AP2 associated kinase 1 AP2-associated protein kinase 1|adaptor-associated kinase 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on AAK1, check out the AAK1 Infographic

AAK1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for AAK1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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Size

Total: $449

SKU:A05368

Backordered.

Lead time for this item is typically 4-7 days

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Eddy test
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A05368
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$449.00

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