Product Info Summary
SKU: | A03723 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IHC, WB |
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Product info
Product Name
Anti-AChR Alpha 1 (E217) CHRNA1 Antibody
View all Nicotinic Acetylcholine R alpha 1/CHRNA1 Antibodies
SKU/Catalog Number
A03723
Size
100ul
Form
Liquid
Description
Boster Bio Anti-AChR Alpha 1 (E217) CHRNA1 Antibody catalog # A03723. Tested in WB,IHC applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-AChR Alpha 1 (E217) CHRNA1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03723)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from internal of human ELF4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A03723 is reactive to CHRNA1 in Human, Mouse, Rat
Applications
A03723 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
54.546kDa
Background of Nicotinic Acetylcholine R alpha 1/CHRNA1
Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter By similarity. Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2 By similarity. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. UniProtKB Q9Z2U4
Miyazaki Y., Oncogene 13:1721-1729(1996).
Aryee D.N.T., Gene 210:71-78(1998).
Ross M.T., Nature 434:325-337(2005).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1000
IHC: 1:50-1:200
Validation Images & Assay Conditions
Click image to see more details
Immunohistochemistry (IHC) analyzes of AChRα1 (E217) pAb bin paraffin-embedded human liver carcinoma tissue at 1:50,showing membrnae and cytoplasmic staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.
Click image to see more details
Immunohistochemistry (IHC) analyzes of AChRα1 (E217) pAb bin paraffin-embedded human kidney carcinoma tissue at 1:50,showing membrnae and cytoplasmic staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.
Click image to see more details
Western blot (WB) analysis of AChRα1 (E217) pAb at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:PC3 whole cell lysate(40ug) Lane4:CT26 whole cell lysate(40ug) Lane5:H9C2 whole cell lysate(40ug)
Protein Target Info & Infographic
Gene/Protein Information For CHRNA1 (Source: Uniprot.org, NCBI)
Gene Name
CHRNA1
Full Name
Acetylcholine receptor subunit alpha
Weight
54.546kDa
Superfamily
ligand-gated ion channel (TC 1.A.9) family
Alternative Names
acetylcholine receptor subunit alpha; ACHRA; ACHRD; CHNRA; cholinergic receptor, nicotinic, alpha 1 (muscle); CHRNA; CHRNA1; CMS2A; FCCMS; nAChR alpha 1; nAchRa1; Nicotinic Acetylcholine R alpha 1 ; Nicotinic Acetylcholine Ra1 ; nicotinic acetylcholine receptor alpha subunit; nicotinic cholinergic receptor alpha 1; nicotinic, alpha polypeptide 1 (muscle); SCCMS CHRNA1 ACHRA, ACHRD, CHRNA, CMS1A, CMS1B, CMS2A, FCCMS, SCCMS cholinergic receptor nicotinic alpha 1 subunit acetylcholine receptor subunit alpha|acetylcholine receptor, nicotinic, alpha 1 (muscle)|cholinergic receptor, nicotinic alpha 1|cholinergic receptor, nicotinic, alpha 1 (muscle)|cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)|muscle nicotinic acetylcholine receptor|nicotinic acetylcholine receptor alpha subunit|nicotinic cholinergic receptor alpha 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CHRNA1, check out the CHRNA1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CHRNA1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-AChR Alpha 1 (E217) CHRNA1 Antibody (A03723)
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No publications found for A03723
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