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Product Info Summary
|Reactive Species:||Human, Mouse, Rat|
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Anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody
Boster Bio Anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody catalog # PA1203. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Nicotinic Acetylcholine Receptor alpha 1/CHRNA1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1203)
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
A synthetic peptide corresponding to a sequence at the N-terminus of human Nicotinic Acetylcholine Receptor alpha 1 (22-36aa EHETRLVAKLFKDYS), identical to the related rat sequence, different from the related mouse sequence by one amino acid.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
No cross reactivity with other proteins
PA1203 is reactive to CHRNA1 in Human, Mouse, Rat
PA1203 is guaranteed for WB Boster Guarantee
Background of Nicotinic Acetylcholine R alpha 1/CHRNA1
CHRNA, also termed ACHRA, is mapped on 2q24-q32.This gene encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis. The protein-coding sequence of the human alpha subu gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule.
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.
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Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.
Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse
Validation Images & Assay Conditions
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Anti-Nicotinic Acetylcholine Receptor alpha 1 antibody, PA1203, Western blotting
WB: Rat Skeletal Muscle Tissue Lysate
Gene/Protein Information For CHRNA1 (Source: Uniprot.Org, NCBI)
Acetylcholine receptor subunit alpha
ligand-gated ion channel (TC 1.A.9) family
acetylcholine receptor subunit alpha; ACHRA; ACHRD; CHNRA; cholinergic receptor, nicotinic, alpha 1 (muscle); CHRNA; CHRNA1; CMS2A; FCCMS; nAChR alpha 1; nAchRa1; Nicotinic Acetylcholine R alpha 1 ; Nicotinic Acetylcholine Ra1 ; nicotinic acetylcholine receptor alpha subunit; nicotinic cholinergic receptor alpha 1; nicotinic, alpha polypeptide 1 (muscle); SCCMS CHRNA1 ACHRA, ACHRD, CHRNA, CMS1A, CMS1B, CMS2A, FCCMS, SCCMS cholinergic receptor nicotinic alpha 1 subunit acetylcholine receptor subunit alpha|acetylcholine receptor, nicotinic, alpha 1 (muscle)|cholinergic receptor, nicotinic alpha 1|cholinergic receptor, nicotinic, alpha 1 (muscle)|cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)|muscle nicotinic acetylcholine receptor|nicotinic acetylcholine receptor alpha subunit|nicotinic cholinergic receptor alpha 1*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
For more info on CHRNA1, check out the CHRNA1 Infographic
We have 30,000+ of these available, one for each gene! check them out.
In this infographic you will see the following information for CHRNA1: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]
PA1203 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Su Y,Ahn B,Macpherson PCD,Ranjit R,Claflin DR,Van Remmen H,Brooks SV.Transgenic expression of SOD1 specifically in neurons of Sod1 deficient mice prevents defects in muscle mitochondrial function and calcium handling.Free Radic Biol Med.2021 Feb 6:S0891-5
PA1203 usage in article: APP:WB, SAMPLE:LIVER,MUSCLE AND SPINAL CORD, DILUTION:1:1000
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