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Product Info Summary
| SKU: | A04743 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Acinus ACIN1 Antibody
SKU/Catalog Number
A04743
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Acinus ACIN1 Antibody (Catalog # A04743). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.
Storage & Handling
Acinus antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Acinus ACIN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04743)
Host
Rabbit
Contents
Acinus Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Acinus antibody was raised against a peptide corresponding to amino acids near the C-terminus of the cleaved active peptide p17, which are identical to those of mouse Acinus. The immunogen is located within amino acids 1050 - 1100 of Acinus.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
NKX2-2 antibody is predicted to not cross-react with other NK2 homeobox family members.
Reactive Species
A04743 is reactive to ACIN1 in Human
Applications
A04743 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
151.862kDa
Background of Acinus
Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS'.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Acinus antibody can be used for detection of Acinus by Western blot at 1 μg/mL. An approximate 220 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Acinus in K562 whole cell lysate with Acinus antibody (CP) at 1 μg/mL.
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Immunocytochemistry staining of K562 cells using Acinus antibody at 10 μg/mL.
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Immunofluorescence of Acinus in Hela cells with Acinus antibody at 10 μg/mL.
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Immunofluorescence of Acinus in K562 cells with Acinus antibody at 20 μg/ml.
Green: Acinus Antibody (A04743)
Blue: DAPI staining
Protein Target Info & Infographic
Gene/Protein Information For ACIN1 (Source: Uniprot.org, NCBI)
Gene Name
ACIN1
Full Name
Apoptotic chromatin condensation inducer in the nucleus
Weight
151.862kDa
Alternative Names
Acinus; ACN; apoptotic chromatin condensation inducer 1; apoptotic chromatin condensation inducer in the nucleus; fSAP152; functional spliceosome-associated protein 152; KIAA0670DKFZp667N107 ACIN1 ACINUS, ACN, fSAP152 apoptotic chromatin condensation inducer 1 apoptotic chromatin condensation inducer in the nucleus|functional spliceosome-associated protein 152
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ACIN1, check out the ACIN1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ACIN1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Acinus ACIN1 Antibody (A04743)
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No publications found for A04743
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