Anti-AF4/FMR2 family member 1 AFF1 Antibody

Product Name

Anti-AF4/FMR2 family member 1 AFF1 Antibody

View all AF4 Antibodies

SKU/Catalog Number

A02590

Size

100ul

Form

Liquid

Description

Boster Bio Anti-AF4/FMR2 family member 1 AFF1 Antibody catalog # A02590. Tested in WB,IHC,ICC/IF applications. This antibody reacts with Human,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-AF4/FMR2 family member 1 AFF1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02590)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human PC-PLD2 around the phosphorylation site of Y169.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02590 is reactive to AFF1 in Human, Rat

Applications

A02590 is guaranteed for IF, IHC, ICC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

131.422kDa

Background of AF4

Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (). Recruits histone deacetylases and DNA methyltransferases.

Hendrich B., Mol. Cell. Biol. 18:6538-6547(1998).
Grimwood J., Nature 428:529-535(2004).
Tatematsu K., Genes Cells 5:677-688(2000).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000
IHC: 1:50-1:200
ICC/IF: 1:50-1:100

Validation Images & Assay Conditions

There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.

Gene/Protein Information For AFF1 (Source: Uniprot.org, NCBI)

Alternative Names

AF-4; AF4/FMR2 family member 1; AF4/FMR2 family, member 1; AF4myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog);translocated to, 2; ALL1-fused gene from chromosome 4 protein; FEL; MLLT2MGC134969; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 2; PBM1; pre-B-cell monocytic leukemia partner 1; Protein AF-4; Protein FEL; Proto-oncogene AF4 AFF1 AF4, MLLT2, PBM1 AF4/FMR2 family member 1 AF4/FMR2 family member 1|ALL1-fused gene from chromosome 4 protein|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2|pre-B-cell monocytic leukemia partner 1|proto-oncogene AF4

For more info on AFF1, check out the AFF1 Infographic

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In this infographic, you will see the following information for AFF1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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