Product Info Summary
SKU: | A05356-1 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Aipl1 Antibody
SKU/Catalog Number
A05356-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Aipl1 Antibody (Catalog # A05356-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Aipl1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Aipl1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05356-1)
Host
Rabbit
Contents
Aipl1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Aipl1 antibody was raised against a 18 amino acid synthetic peptide near the center of the human Aipl1. The immunogen is located within amino acids 140 - 190 of Aipl1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A05356-1 is reactive to AIPL1 in Human, Mouse, Rat
Applications
A05356-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
43.903kDa
Background of AIPL1
Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Aipl1 antibody can be used for detection of Aipl1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Aipl1 in rat brain tissue lysate with Aipl1 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of Aipl1 in human brain tissue with Aipl1 antibody at 2.5 μg/mL.
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Immunofluorescence of aipl1 in human brain tissue with aipl1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For AIPL1 (Source: Uniprot.org, NCBI)
Gene Name
AIPL1
Full Name
Aryl-hydrocarbon-interacting protein-like 1
Weight
43.903kDa
Alternative Names
AIPL2; aryl hydrocarbon receptor interacting protein-like 1; aryl hydrocarbon receptor-interacting protein-like 1; aryl-hydrocarbon-interacting protein-like 1; LCA4 AIPL1 AIPL2, LCA4 aryl hydrocarbon receptor interacting protein like 1 aryl-hydrocarbon-interacting protein-like 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on AIPL1, check out the AIPL1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for AIPL1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Aipl1 Antibody (A05356-1)
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