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Product Info Summary
| SKU: | A12102 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Akirin-1 Akirin1 Antibody
SKU/Catalog Number
A12102
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Akirin-1 Akirin1 Antibody (Catalog # A12102). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Akirin1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Akirin-1 Akirin1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12102)
Host
Rabbit
Contents
Akirin1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Akirin1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of the human Akirin1. The immunogen is located within the first 50 amino acids of Akirin1.
Reactive Species
A12102 is reactive to AKIRIN1 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
21.9 kDa
Background of AKIRIN1
The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α and IL-1β signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A12102 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Akirin1 antibody can be used for detection of Akirin1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Akirin1 in A549 cell lysate with Akirin1 antibody at (A) 1 and (B) 2 μg/mL.
Specific Publications For Anti-Akirin-1 Akirin1 Antibody (A12102)
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