Product Info Summary
SKU: | A11286 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Apoptosis-inducing factor 3 AIFM3 Antibody
SKU/Catalog Number
A11286
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Apoptosis-inducing factor 3 AIFM3 Antibody (Catalog # A11286). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
AIFM3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Apoptosis-inducing factor 3 AIFM3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11286)
Host
Rabbit
Contents
AIFM3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
AIFM3 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human AIFM3. The immunogen is located within the first 50 amino acids of AIFM3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A11286 is reactive to Aifm3 in Human, Mouse, Rat
Applications
A11286 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
66.792kDa
Background of Aifm3
Apoptosis, also known as programmed cell death, plays major roles in development and normal tissue turnover in addition to tumor formation. Recently a protein similar to the apoptosis-inducing factor (AIF) was cloned and designated AIFL (also known as AIFM3). AIFM3 is expressed ubiquitously and is predominantly localized to the inner membranes of mitochondria. Unlike AIF, AIFM3 does not translocate to the nucleus upon induction of apoptosis. However, overexpression of AIFM3, like AIF, induced cytochrome c release from the mitochondria, cleavage of caspase 3, and ultimately apoptosis, indicating AIFM3 induces apoptosis through caspase activation. Multiple isoforms of AIFM3 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
AIFM3 antibody can be used for the detection of AIFM3 by Western blot at 0.5 and 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of NIPSNAP in human brain tissue lysate with NIPSNAP antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunohistochemical staining of human brain tissue using AIFM3 antibody at 2.5 μg/mL.
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Immunofluorescence of AIFM3 in human brain tissue with AIFM3 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Aifm3 (Source: Uniprot.org, NCBI)
Gene Name
Aifm3
Full Name
Apoptosis-inducing factor 3
Weight
66.792kDa
Superfamily
FAD-dependent oxidoreductase family
Alternative Names
AIFLFLJ30473; apoptosis-inducing factor 3; apoptosis-inducing factor like; apoptosis-inducing factor, mitochondrion-associated, 3; Apoptosis-inducing factor-like protein; FLJ45137
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Aifm3, check out the Aifm3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Aifm3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Apoptosis-inducing factor 3 AIFM3 Antibody (A11286)
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No publications found for A11286
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