Product Info Summary
SKU: | M01186 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Mouse |
Application: | ELISA, IHC |
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Product info
Product Name
Anti-BNP NPPB Monoclonal Antibody (KLH)
SKU/Catalog Number
M01186
Size
100ul
Form
Liquid
Description
Boster Bio Anti-BNP NPPB Monoclonal Antibody (KLH) catalog # M01186. Tested in ELISA, IHC applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-BNP NPPB Monoclonal Antibody (KLH) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01186)
Host
Mouse
Contents
Ascitic fluid containing 0.03% sodium azide.
Clonality
Monoclonal
Clone Number
8D5B4C11
Isotype
IgG
Immunogen
Synthesized peptide derived from human BNP, conjugated to KLH.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
M01186 is reactive to NPPB in Human
Applications
M01186 is guaranteed for ELISA, IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
14.726kDa
Background of BNP
TRPC6, also known as TRP6, short transient receptor potential channel 6 and transient receptor potential cation channel subfamily C member 6, is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC6 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. It is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C and may not to be activated by intracellular calcium store depletion. Defects in this gene are a cause of focal segmental glomerulosclerosis (FSGS). Expression of this protein has been reported in tissues such as placenta, lung, spleen, ovary, small intestine, and renal podocytes. Immunohistochemistry studies using polyclonal antibodies to this target have shown moderate to strong staining in cell types such as neurons, breast, respiratory, squamous and prostate epithelium, epidermis, placental trophoblasts, dendritic cells, and subsets of immune cells, and faint to moderate staining of adrenal, colon, ganglion cells, hepatocytes, heart, and testis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC 1:200-1:1000
ELISA 1:10000
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunohistochemistry validation of NPPB using Anti-BNP NPPB Monoclonal Antibody (KLH) (M01186).
Immunohistochemistry (IHC) analysis of paraffin-embedded human normal myocardiumProtein Target Info & Infographic
Gene/Protein Information For NPPB (Source: Uniprot.org, NCBI)
Gene Name
NPPB
Full Name
Natriuretic peptides B
Weight
14.726kDa
Superfamily
natriuretic peptide family
Alternative Names
BNF; BNP; brain type natriuretic peptide; Gamma-brain natriuretic peptide; natriuretic peptide B; natriuretic peptide precursor B; natriuretic peptides B; natriuretic protein; NPPB NPPB BNP, Iso-ANP natriuretic peptide B natriuretic peptides B|brain natriuretic factor prohormone|brain type natriuretic peptide|gamma-brain natriuretic peptide|natriuretic peptide precursor B|natriuretic protein|preproBNP|proBNP
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on NPPB, check out the NPPB Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for NPPB: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-BNP NPPB Monoclonal Antibody (KLH) (M01186)
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No publications found for M01186
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