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- Table of Contents
Natriuretic peptides B Antibodies
AND NPPB ELISA kits, Natriuretic peptides B Proteins
Many biological assays use antibodies to detect Natriuretic peptides B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Natriuretic peptides B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Natriuretic peptides B antibodies...
Designing a Western blot for Natriuretic peptides B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the NPPB Western Blot GuideNPPB Infographic by Boster Bio
All NPPB Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1628
96 wells/kit, with removable strips.
Cat # EK1628
96 wells/kit, with removable strips.
NPPB Overview
Facts about Natriuretic peptides B.
Natriuretic peptides B (NPPB)
Cardiac hormone which might be a paracrine antifibrotic element in the heart. Also plays an integral role in cardiovascular homeostasis via natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion.
Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
Gene Information
| Human | |
|---|---|
| Gene Name: | NPPB |
| Uniprot: | P16860 |
| Entrez: | 4879 |
Family
| Belongs to: |
|---|
| natriuretic peptide family |
Alternative Names
BNF; BNP; brain type natriuretic peptide; Gamma-brain natriuretic peptide; natriuretic peptide B; natriuretic peptide precursor B; natriuretic peptides B; natriuretic protein; NPPB
Molecular Weight
Mass (kDA):
14.726 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.22 |
| Sequence: | 1; NC_000001.11 (11857464..11858945, complement) |
Tissue Specificity
Brain and also in atria, but at much lower levels than ANP.
Subcellular Localizations
Secreted.
Diseases
- Edema
- Fibrosis
- Cystic Fibrosis
- Malignant Neoplasms
- Carcinoma
- Ischemia
- Arteriovenous Malformation
- Neoplasms
- Hypertrophy
- Intracranial Arteriovenous Malformation
- Hypertensive Disease
- Cancer Of Nasopharynx
- Aqueous Humor Disorders
Interacting Proteins
- KRT40
- KRTAP10-9
- NOTCH2NL
- PSMA3
Pathways
- Transport
- Secretion
- Ion Transport
- Cell Proliferation
- Membrane Depolarization
- Chloride Transport
- Anion Transport
- Cell Cycle
- Exocytosis
- Localization
- Cell Death
- Pathogenesis
- Excretion
PTMs
- Phosphorylation
- Reduction
- Carboxylation
- Nitration
- Cleavage
Research Areas
- Cytokine Research
- Immunology
- Neuroscience
- Neurotransmission
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPPB
bosterbio.com/bosterbio-gene-info-cards/NPPB
References
PMID: 2597152 by Seilhamer J.J., et al. Human and canine gene homologs of porcine brain natriuretic peptide.
PMID: 2522777 by Sudoh T., et al. Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide.