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Product Info Summary
| SKU: | A00934 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-Bone marrow stromal antigen 2 Bst2 Antibody
SKU/Catalog Number
A00934
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Bone marrow stromal antigen 2 Bst2 Antibody (Catalog # A00934). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
Bst2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Bone marrow stromal antigen 2 Bst2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00934)
Host
Rabbit
Contents
Bst2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Bst2 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of the mouse Bst2. The immunogen is located within amino acids 60 - 110 of Bst2.
Reactive Species
A00934 is reactive to BST2 in Human, Mouse
Observed Molecular Weight
68 kDa
Calculated molecular weight
19.2 kDa
Background of BST2
Bst2 was first identified as a novel terminal B-cell-restricted antigen termed HM1.24 that is expressed on certain bone marrow cells as well as other tissues. The surface expression of Bst2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line, suggesting that this protein is involved in pre-B-cell growth. Later experiments also showed it to be upregulated in several myeloma cells. More recently, Bst2 was identified an inhibitor of retroviral release from human cells whose activity is antagonized by the HIV-1 accessory protein Vpu. While Bst2 caused retention of virions on cell surfaces or endocytosis into Bst2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release. This activity may represent a potential therapeutic strategy for the treatment of HIV/AIDS.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00934 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Bst2 antibody can be used for detection of Bst2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Bst2 in Daudi cell lysate with Bst2 antibody at (A) 1 and (B) 2 μg/mL.
Specific Publications For Anti-Bone marrow stromal antigen 2 Bst2 Antibody (A00934)
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