Anti-CAND2 Antibody

Product Name

Anti-CAND2 Antibody

View all TIP120B Antibodies

SKU/Catalog Number

A10530

Size

100uL

Form

Liquid (sterile filtered)

Description

Boster Bio Anti-CAND2 Antibody (Catalog # A10530). Tested in IP, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store CAND2 antibody at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Cite This Product

Anti-CAND2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10530)

Host

Rabbit

Contents

0.01% (w/v) Sodium Azide

Clonality

Polyclonal

Isotype

Antiserum

Immunogen

This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1130-1143 of Human CAND2/TIP120B (C-terminal) coupled to KLH.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A10530 is reactive to CAND2 in Human, Mouse, Rat

Applications

A10530 is guaranteed for IP, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

135.256kDa

Background of TIP120B

Anti-CAND2 antibody is ideal for western blotting, ELISA and IHC. CAND2 is also known as TIP120B, and TATA-binding protein-interacting protein 120B. While both CAND1 (TIP120A) and CAND2 (TIP120B) are TATA-binding proteins and form complexes with various nuclear proteins involved in the control of eukaryotic gene transcription, CAND2 (TIP120B) is expressed specifically in muscle and heart tissue. This is contrary to the ubiquitous expression of CAND1 (TIP120A). TIP120 homologs exist in various higher eukaryotes including D. melanogaster, C. elegans, and A. thaliana. TIP120B is 60% identical in amino acid sequence to TIP120A.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

ELISA: 1:2,000 - 1:10,000
IHC: User optimized
IP: User optimized
WB: 1:500 - 1:1,000

Validation Images & Assay Conditions

Click image to see more details

Most modifiers mature by proteolytic processing from inactive precursors (a; amino acid). Arrowheads point to the cleavage sites. Ubiquitin is expressed either as polyubiquitin or as a fusion with ribosomal proteins. Conjugation requires activating (E1) and conjugating (E2) enzymes that form thiolesters (S) with the modifiers. Modification of cullins by RUB involves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin-2/elongin B/elonginC) -like E3 enzymes that are also involved in ubiquitination. In contrast to ubiquitin, the UBLs do not seem to form multi-UBL chains. UCRP(ISG15) resembles two ubiquitin moieties linked head-to-tail. Whether HUB1 functions as a modifier is currently unclear. APG12 and URM1 are distinct from the other modifiers because they are unrelated in sequence to ubiquitin.Data contributed by S.Jentsch.

Gene/Protein Information For CAND2 (Source: Uniprot.org, NCBI)

Alternative Names

cullin-associated and neddylation-dissociated 2 (putative); Cullin-associated and neddylation-dissociated protein 2; cullin-associated NEDD8-dissociated protein 2; epididymis tissue protein Li 169; KIAA0667TBP-interacting protein of 120 kDa B; p120 CAND2; TBP interacting protein; TBP-interacting protein 120B; TIP120BTp120b CAND2 TIP120B, Tp120b cullin associated and neddylation dissociated 2 (putative) cullin-associated NEDD8-dissociated protein 2|TBP interacting protein|TBP-interacting protein 120B|TBP-interacting protein of 120 kDa B|cullin-associated and neddylation-dissociated protein 2|epididymis secretory sperm binding protein|epididymis tissue protein Li 169|p120 CAND2

For more info on CAND2, check out the CAND2 Infographic

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In this infographic, you will see the following information for CAND2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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