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Product Info Summary
| SKU: | M00587 |
|---|---|
| Size: | 100ug/vial |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | IHC |
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Product info
Product Name
Anti-CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa (Platelet Marker) ITGB3 Monoclonal Antibody
View all Integrin beta 3/CD61 Antibodies
SKU/Catalog Number
M00587
Size
100ug/vial
Form
Liquid
Description
Boster Bio Anti-CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa (Platelet Marker) ITGB3 Monoclonal Antibody (Catalog # M00587). Tested in IHC applications. This antibody reacts with Human.
Storage & Handling
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Cite This Product
Anti-CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa (Platelet Marker) ITGB3 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00587)
Host
Mouse
Contents
Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Clonality
Monoclonal
Clone Number
Clone: ITGB3/1713
Isotype
IgG1, kappa
Immunogen
Recombinant human ITGB3 protein
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Does not cross-react with primate, avian or amphibian GR.
Reactive Species
M00587 is reactive to ITGB3 in Human
Applications
M00587 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
87.058kDa
Background of Integrin beta 3/CD61
Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61).The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Reconsitution
Reconstitute with distilled water.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Frozen & Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.
Validation Images & Assay Conditions
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Formalin-fixed, paraffin-embedded human Spleen stained with Anti-CD61 Mouse Monoclonal Antibody (ITGB3/1713).
Protein Target Info & Infographic
Gene/Protein Information For ITGB3 (Source: Uniprot.org, NCBI)
Gene Name
ITGB3
Full Name
Integrin beta-3
Weight
87.058kDa
Superfamily
integrin beta chain family
Alternative Names
CD61 antigen; CD61; GP3A; GP3Aplatelet glycoprotein IIIa; GPIIIA; GPIIIaintegrin beta-3; INGRB3; Integrin beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITG B3; ITGB3; Platelet membrane glycoprotein IIIa ITGB3 BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT integrin subunit beta 3 integrin beta-3|antigen CD61|integrin beta 3|integrin beta chain, beta 3|integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)|platelet membrane glycoprotein IIIa
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ITGB3, check out the ITGB3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ITGB3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CD61 / Integrin beta-3 / Platelet Glycoprotein IIIa (Platelet Marker) ITGB3 Monoclonal Antibody (M00587)
Hello CJ!
M00587 has been cited in 3 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Construction of drug screening cell model and application to new compounds inhibiting FITC-fibrinogen binding to CHO cells expressing human αIIbβ3
Correlation of integrin %u03B23 mRNA and vascular endothelial growth factor protein expression profiles with the clinicopathological features and prognosis of %u2026
Study on the Expression and Clinical Significances of Lewis y Antigen and Integrin ?v, ?3 in Epithelial Ovarian Tumors
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