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- Table of Contents
Integrin beta-3 Antibodies
AND ITGB3 ELISA kits, Integrin beta-3 Proteins
Many biological assays use antibodies to detect Integrin beta-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin beta-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin beta-3 antibodies...
Designing a Western blot for Integrin beta-3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ITGB3 Western Blot GuideITGB3 Infographic by Boster Bio
All ITGB3 Products
Product
Figures
Specificity
Applications
Price
Anti-Integrin beta 3/ITGB3 Antibody Picoband®
4 Citations
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1627
100 μg/vial
Cat # PA1627
100 μg/vial
Anti-Integrin beta 3/ITGB3 Antibody Picoband®
1 Citations
Human, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00587-1
100 μg/vial
Cat # A00587-1
100 μg/vial
Human
ELISA, IF, ICC, WB
$370
Cat # A09098-1
100 µg/vial
Cat # A09098-1
100 µg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00587-1
100 μl
Cat # M00587-1
100 μl
Human
IP, IHC, WB
$370
Cat # M00587-2
100 μl/vial
Cat # M00587-2
100 μl/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00587-3
20μL, 40μL, 100μL, 200μL
Cat # M00587-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2436
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2436
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2435
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2435
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA
$480
Cat # EKC1304
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1304
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01933-1
100 μg
Cat # M01933-1
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01561-3
100 μg
Cat # M01561-3
100 μg
Human
ELISA, Flow Cytometry, Functional Assay, Kinetics
$486
Cat # M01102-4
100 μg
Cat # M01102-4
100 μg
ITGB3 Overview
Facts about Integrin beta-3.
Integrin beta-3 (ITGB3)
Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.
Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step results in rapid platelet aggregation which plugs ruptured endothelial surface.
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGB3 |
| Uniprot: | P05106 |
| Entrez: | 3690 |
Family
| Belongs to: |
|---|
| integrin beta chain family |
Alternative Names
CD61 antigen; CD61; GP3A; GP3Aplatelet glycoprotein IIIa; GPIIIA; GPIIIaintegrin beta-3; INGRB3; Integrin beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITG B3; ITGB3; Platelet membrane glycoprotein IIIa
Molecular Weight
Mass (kDA):
87.058 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.32 |
| Sequence: | 17; NC_000017.11 (47253827..47313743) |
Tissue Specificity
Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane. Cell junction, focal adhesion. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Cell junction, synapse.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Thrombasthenia
- Hemorrhage
- Neoplasms
- Myocardial Infarction
- Infarction
- Neoplasm Metastasis
- Von Willebrand Disease
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cardiovascular Diseases
Interacting Proteins
- CX3CL1
- FLNA
- ITGA2B
- ITGAV
- PLA2G2A
- Prkd1
- PTPN1
- Src
- TLN1
- Tln1
Pathways
- Platelet Aggregation
- Pathogenesis
- Platelet Activation
- Hemostasis
- Angiogenesis
- Cell Adhesion
- Coagulation
- Secretion
- Cell Migration
- Cell Proliferation
- Inflammatory Response
- Mrna Splicing
- Sensitization
PTMs
- Phosphorylation
- Methylation
- Demethylation
Research Areas
- Cancer
- Cell Biology
- Cellular Markers
- Phospho-Specific
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGB3
bosterbio.com/bosterbio-gene-info-cards/ITGB3
References
PMID: 3494014 by Fitzgerald L.A., et al. Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to 'integrin'.
PMID: 2452834 by Zimrin A.B., et al. Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors.
4 Publications of Boster Integrin beta-3 Antibodies & ELISA Kits
- PubMed ID: 33536035, Zhou L,Li C,Liu X,Zhang T.Effect of Irisin on LIF and integrin αvβ3 in rats of...
- PubMed ID: 18200665, Correlation of integrin %u03B23 mRNA and vascular endothelial growth factor prot...
- PubMed ID: 21747684, Study on the Expression and Clinical Significances of Lewis y Antigen and Integr...
- PubMed ID: 26857387, TGF?3-mediated induction of Periostin facilitates head and neck cancer growth an...
*More publications can be found for each product on its corresponding product page