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4 Citations 3 Q&As
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3 Citations 1 Q&As
Facts about Integrin beta-3.
Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step results in rapid platelet aggregation which plugs ruptured endothelial surface.
Human | |
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Gene Name: | ITGB3 |
Uniprot: | P05106 |
Entrez: | 3690 |
Belongs to: |
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integrin beta chain family |
CD61 antigen; CD61; GP3A; GP3Aplatelet glycoprotein IIIa; GPIIIA; GPIIIaintegrin beta-3; INGRB3; Integrin beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITG B3; ITGB3; Platelet membrane glycoprotein IIIa
Mass (kDA):
87.058 kDA
Human | |
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Location: | 17q21.32 |
Sequence: | 17; NC_000017.11 (47253827..47313743) |
Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane. Cell junction, focal adhesion. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Cell junction, synapse.
When it is time to diagnose and test Sickle Cell Anemia, there are a variety of factors that come into play. Antibodies to Fibrinogen gamma chain and Anti-Phospho-Integrin beta (Y773) can be of help. They have their limitations. To make an informed choice you must find out more about these markers.
A rabbit polyclonal antibody against human Integrin b3 the phosphorylation site Y773 can be found. The antibody binds to a synthetic peptide which is derived from human Integrin b3 as well the phosphorylation site of Y773. The antibody is reduced to 1:50 ratio in buffer comprising 50% glycerol, 0.5% BSA and 0.02 percent sodium azide. It will be shipped within 5-10 days. It is designed to be used for research purposes only.
The antibody recognizes both phosphorylated FAK as well as non-phosphorylated FAK. These antibodies can be bought from Bioworld Technology, which is based in St. Louis Park (MN), USA. Santa Cruz Biotechnology supplies the anti-PECAM-1 antibody. The Integrin AVB3 antibody is available from Millipore. It is available in a variety of concentrations.
Multiple phosphorylation sites form the CT domain of the integrin b3 subunit. It has a tyrosine-containing residue as well as a serine, and multiple threonine phosphorylation sites. This NPXY-like motif can be recognized by talin as well as kindlin. In this way, the drug blocks the migration and invasion of tumor cells.
This antibody is able to inhibit the negative regulator of function of integrin, the junctional adhesive molecule A. This negative regulator of integrin function provides protection against the thrombosis. It is also a highly effective cancer therapy. The agents are currently being tested in clinical trials. The Anti-Phospho-Integrin beta (Y773) antibody can be used to treat various cancers and conditions.
The ITGB3 marker is a hematologic tumor marker which can be utilized in many cancer tests. The ITGB3 marker can be found on cells' surfaces at normal levels. It also functions following extracellular stimulation. It is not be activated through "inside out" signaling pathways. This biomarker is especially useful in studies of hematologic cancers.
Many biological assays make use of antibodies to ITGB3. These antibodies can be monoclonal as well as polyclonal and can be reacted with a wide range of animal specimens. Boster Bio uses rabbit and mouse to create its antibodies against this marker. ITGB3 is located on the fibrinogen gamma chain. The ITGB3 marker is expressed in a variety of tissues, including the kidney and liver, and is mainly found in the intestine, the skin, and the spleen.
A recent study has revealed a link between levels of g' fibrinogen as well as the risk for cardiovascular disease. This association is still not recognized. Researchers conducted a genome-wide research of 3042 participants from the Framingham Heart Study offspring cohort. Researchers discovered that rs7681423 (and rs1049636) are associated with g fibrinogen levels. These SNPs are linked to linkage imbalance which means that they are most likely to cause the largest changes.
The Fibrinogen gamma chain is detected in many biological assays. Antibodies to this protein are either monoclonal or polyclonal. The antibodies react with fibrinogen gamma chains in numerous animal specimens. Boster Bio uses rabbits and mice as their model species. Antibodies to FGB are essential to form thrombuses.
The G fibrinogen ELISA method was used to determine the amount of g' fibrinogen present in plasma. The plasma was then defibrinated 56°C and centrifuged at 100,000xg for 30 minutes. The plasma was then dilute in 0.1% fraction BSA in PBS which contained five mg/L of EDTA. The EDTA was dissolved in 0.1 percent Triton X-100. The same buffer was used to dissolve the plasma that was heat-defibrinated.
The fibrinogen G chain does not have the AGDV residues in its C-terminal area. It is believed to bind platelet integrin (aIIbb3). This is a new method to differentiate between gamma and chains in plasma. Fibrinogen g' could be paired with different forms of the alpha-chain.
Utilizing an ITGB3 marker to assess the progression of sickle cells has advantages and disadvantages. This new blood test may help to decrease the need for transfusions for children suffering from sickle cell anemia. Researchers are exploring how it could improve patient outcomes. A study from the past suggests that ITGB3 might be useful in identifying patients who are at high risk of developing sickle-cell disease.
The ITGB3 marker is a monoclonal antibodies that recognizes the H-L-G-G. in the fibrinogen gamma chain. Boster Bio developed the antibodies in rabbit and mouse cells. The ITGB3 antibody is a biomarker of sickle cell anemia. It detects the presence c-Myc haploinsufficiency.
Recent research published in Blood revealed that the ITGB3 marker can be used to diagnose and treat sickle cell anemia. It was developed to detect the root cause of the disease in patients at high risk of having sickle cell anemia. Its results were promising in both humans and mice. ITGB3 is now being used to detect sickle cell disease in patients with high-risk phenotypes.
The ITGB3 marker is widely used for treatment of sickle cells anemia. It is also utilized to treat patients suffering from May-Thurner syndrome and XIAP deficiency. These results prove the ITGB3 marker's usefulness in detecting sickle cell anemia. The results of this study can be used to monitor the treatment of sickle cells and in the development of new diagnostics.
This integrin is expressed on various types of cancerous cells. These include non-small cell lung cancer, breast and cervical cancers, and pancreatic adenocarcinoma. Its high specificity for avb3 integrins allows it to distinguish between ligands that have the RGD tripeptide and those that don't. It is also present on tumor cells of many kinds of cancers and can be an effective biomarker for targeted treatment of these cancers.
It is a vital biomarker for cancer cells because of its critical function in the formation of heterogeneous tumor cells, metabolic reprogramming and the heterogeneity of tumor cells. It is involved in a variety of steps of angiogenesis in tumors. This involves regulating cholesterol and glucose metabolism, as well as being associated with metabolic restructuring. The overexpression of it in tumors is caused by hypoxic and acidic environments and is associated with increased invasion and migration.
When combined with tumor cells, cilengitide has demonstrated efficacy in EGFRvIII-tumors. Non-treated tumors had necrosis focal to the area. Those who received the drug experienced an increase in HIF-1a staining. Inserts revealed hypoxic tumor cells, which resulted in large necrotic areas.
ITGB3 is an important regulator for aging. It is present in human primary fibroblasts where it regulates the expression of TGF-b as well as other cell-cycle genes. It also plays a role in cellular senescence. cells exposed to harmful conditions, such as radiation or ionizing agents aren't in a position to reproduce or spread.
The ITGB3 gene is a unique genetic marker used to study human hematopoiesis. The gene encodes glutamine, an amino acid. It is found in more than half of human blood cells. Its most effective uses are not recognized. However scientists are beginning to realize the significance. Sickle Cell Disease patients have a three-fold increase in the expression of the ITGB3 gene than normal blood cells.
The ITGB3 gene is regulated in a variety of conditions like atrial fibrillation, pelvic organ prolapse. It is also associated with a higher risk of infection in AIDS patients. ITGA9 is also upregulated in the rheumatoid joint (RA). It is therefore essential to identify conditions in which the ITGB3 gene could be overexpressed. Additionally, ITGA9 is involved in the development of autoimmune diseases including HIV and AIDS.
Boster Bio offers an ITGB3 antibody. The antibody's catalog number is A00587Y773 and it reacts with Human, Mouse, and Rat. The antibody can be stored at -20°C for up to one year or at 4°C for as long as one month. Boster Bio validates all antibodies with known positive and negative samples. We recommend purchasing anti-ITGB3 antibodies from a trusted source to ensure optimal results.
PMID: 3494014 by Fitzgerald L.A., et al. Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to 'integrin'.
PMID: 2452834 by Zimrin A.B., et al. Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors.
*More publications can be found for each product on its corresponding product page