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- Table of Contents
Integrin beta-3 Antibodies
AND ITGB3 ELISA kits, Integrin beta-3 Proteins
Many biological assays use antibodies to detect Integrin beta-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin beta-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin beta-3 antibodies...
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ITGB3 Infographic by Boster Bio
All ITGB3 Products
Product
Figures
Specificity
Applications
Price
Anti-Integrin beta 3/ITGB3 Antibody Picoband®
4 Citations 3 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # PA1627
100 μg/vial
Cat # PA1627
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00587-1
100 μl
Cat # M00587-1
100 μl
Human, Mouse
ELISA
$480
Cat # EKC1304
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1304
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2435
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2435
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2436
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2436
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00587Y773-1
100ul
Cat # A00587Y773-1
100ul
Human, Mouse, Rat
ELISA, IF, IHC
$380
Cat # A00587Y785
100ul
Cat # A00587Y785
100ul
Human
IP, IHC, WB
$370
Cat # M00587-2
100 μl/vial
Cat # M00587-2
100 μl/vial
Anti-Integrin beta 3/ITGB3 Antibody Picoband®
1 Citations
Human, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00587-1
100 μg/vial
Cat # A00587-1
100 μg/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00587-3
20μL, 40μL, 100μL, 200μL
Cat # M00587-3
20μL, 40μL, 100μL, 200μL
ITGB3 Overview
Facts about Integrin beta-3.
Integrin beta-3 (ITGB3)
Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.
Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step results in rapid platelet aggregation which plugs ruptured endothelial surface.
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGB3 |
| Uniprot: | P05106 |
| Entrez: | 3690 |
Family
| Belongs to: |
|---|
| integrin beta chain family |
Alternative Names
CD61 antigen; CD61; GP3A; GP3Aplatelet glycoprotein IIIa; GPIIIA; GPIIIaintegrin beta-3; INGRB3; Integrin beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITG B3; ITGB3; Platelet membrane glycoprotein IIIa
Molecular Weight
Mass (kDA):
87.058 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.32 |
| Sequence: | 17; NC_000017.11 (47253827..47313743) |
Tissue Specificity
Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane. Cell junction, focal adhesion. Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein. Cell junction, synapse.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Thrombasthenia
- Hemorrhage
- Neoplasms
- Myocardial Infarction
- Infarction
- Neoplasm Metastasis
- Von Willebrand Disease
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Cardiovascular Diseases
Interacting Proteins
- CX3CL1
- FLNA
- ITGA2B
- ITGAV
- PLA2G2A
- Prkd1
- PTPN1
- Src
- TLN1
- Tln1
Pathways
- Platelet Aggregation
- Pathogenesis
- Platelet Activation
- Hemostasis
- Angiogenesis
- Cell Adhesion
- Coagulation
- Secretion
- Cell Migration
- Cell Proliferation
- Inflammatory Response
- Mrna Splicing
- Sensitization
PTMs
- Phosphorylation
- Methylation
- Demethylation
Research Areas
- Cancer
- Cell Biology
- Cellular Markers
- Phospho-Specific
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGB3
bosterbio.com/bosterbio-gene-info-cards/ITGB3
References
PMID: 3494014 by Fitzgerald L.A., et al. Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to 'integrin'.
PMID: 2452834 by Zimrin A.B., et al. Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors.
4 Publications of Boster Integrin beta-3 Antibodies & ELISA Kits
- PubMed ID: 33536035, Zhou L,Li C,Liu X,Zhang T.Effect of Irisin on LIF and integrin αvβ3 in rats of...
- PubMed ID: 18200665, Correlation of integrin %u03B23 mRNA and vascular endothelial growth factor prot...
- PubMed ID: 21747684, Study on the Expression and Clinical Significances of Lewis y Antigen and Integr...
- PubMed ID: 26857387, TGF?3-mediated induction of Periostin facilitates head and neck cancer growth an...
*More publications can be found for each product on its corresponding product page