Anti-CDNF Antibody

Product Name

Anti-CDNF Antibody

View all Cdnf Antibodies

SKU/Catalog Number

A10069-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-CDNF Antibody (Catalog # A10069-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

CDNF antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-CDNF Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10069-1)

Host

Rabbit

Contents

CDNF Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

CDNF antibody was raised against a 9 amino acid synthetic peptide from near the carboxy terminus of human CDNF. The immunogen is located within the last 50 amino acids of CDNF.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

This antibody does not cross-react with MANF.

Reactive Species

A10069-1 is reactive to Cdnf in Human, Mouse, Rat

Applications

A10069-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

21.032kDa

Background of Cdnf

The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

CDNF antibody can be used for detection of CDNF by Western blot at 2 - 4 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of CDNF in mouse brain tissue lysate with CDNF antibody at (A) 2 and (B) 4 μg/mL.

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Immunohistochemistry of CDNF in human brain tissue with CDNF antibody at 2.5 μg/mL.

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Immunofluorescence of CDNF in Human Brain cells with CDNF antibody at 20 μg/mL.

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Immunohistochemistry of CDNF in mouse brain tissue with CDNF Antibody at 5 μg/mL.

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Immunofluorescence of CDNF in mouse brain tissue with CDNF Antibody at 20 μg/mL.

Green: CDNF Antibody (A10069-1)
Blue: DAPI staining

Gene/Protein Information For Cdnf (Source: Uniprot.org, NCBI)

Alternative Names

arginine-rich, mutated in early stage tumors-like 1; ARMETL1; ARMET-like protein 1; CDNF; cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor Cdnf|9330140G23, Arme, Armetl1|cerebral dopamine neurotrophic factor|cerebral dopamine neurotrophic factor|ARMET-like protein 1|arginine-rich, mutated in early stage tumors-like 1|conserved dopamine neurotrophic factor

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In this infographic, you will see the following information for Cdnf: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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