Product Info Summary
SKU: | A02761 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-CHRNB2 Antibody
View all Nicotinic Acetylcholine Receptor beta 2 Antibodies
SKU/Catalog Number
A02761
Size
100ul
Form
Liquid
Description
Boster Bio Anti-CHRNB2 Antibody catalog # A02761. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-CHRNB2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02761)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Recombinant protein of human CHRNB2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02761 is reactive to CHRNB2 in Human, Mouse, Rat
Applications
A02761 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
57.019kDa
Background of Nicotinic Acetylcholine Receptor beta 2
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Cheung P.C.F., Biochem. J. 346:659-669(2000).
Lang T.M., Genomics 70:258-263(2000).
Ota T., Nat. Genet. 36:40-45(2004).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2000
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of extracts of various cells, using CHRNB2 antibody.
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Immunohistochemistry of paraffin-embedded mouse brain using CHRNB2 antibody at dilution of 1:100 (x40 lens).
Protein Target Info & Infographic
Gene/Protein Information For CHRNB2 (Source: Uniprot.org, NCBI)
Gene Name
CHRNB2
Full Name
Neuronal acetylcholine receptor subunit beta-2
Weight
57.019kDa
Superfamily
ligand-gated ion channel (TC 1.A.9) family
Alternative Names
Cholinergic Receptor Nicotinic Beta 2 Subunit; cholinergic receptor, nicotinic, beta 2 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal); CHRNB2; EFNL3; NAChRB2; neuronal acetylcholine receptor subunit beta-2; Neuronal Nicotinic Acetylcholine R beta 2; neuronal nicotinic acetylcholine receptor beta 2; Nicotinic Acetylcholine R beta 2 CHRNB2 EFNL3, nAChRB2 cholinergic receptor nicotinic beta 2 subunit neuronal acetylcholine receptor subunit beta-2|acetylcholine receptor, nicotinic, beta 2 (neuronal)|beta2 human neuronal nicotinic acetylcholine receptor|cholinergic receptor, nicotinic beta 2|cholinergic receptor, nicotinic, beta 2 (neuronal)|cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)|neuronal nicotinic acetylcholine receptor beta 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CHRNB2, check out the CHRNB2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CHRNB2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CHRNB2 Antibody (A02761)
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No publications found for A02761
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