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Product Info Summary
| SKU: | A02731 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-CLEC7A Antibody
View all Dectin-1/CLEC7A Antibodies
SKU/Catalog Number
A02731
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CLEC7A Antibody (Catalog # A02731). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CLEC7A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-CLEC7A Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02731)
Host
Rabbit
Contents
CLEC7A Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
Clone: SK7
Isotype
IgG
Immunogen
CLEC7A antibody was raised against a 17 amino acid synthetic peptide near the center of human CLEC7A. The immunogen is located within amino acids 70 - 120 of CLEC7A.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of CLEC7A are known to exist.
Reactive Species
A02731 is reactive to Clec7a in Human, Mouse, Rat
Applications
A02731 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
27.42kDa
Background of Dectin-1/CLEC7A
CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CLEC7A antibody can be used for detection of CLEC7A by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CLEC7A in rat spleen tissue lysate with CLEC7A antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of CLEC7A in human spleen tissue with CLEC7A antibody at 5 μg/mL.
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Immunofluorescence of CLEC7A in Jurkat cells with CLEC7A antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For Clec7a (Source: Uniprot.org, NCBI)
Gene Name
Clec7a
Full Name
C-type lectin domain family 7 member A
Weight
27.42kDa
Alternative Names
Beta-glucan receptor; BGR; CD369; CLEC7A; CLECSF12; CLECSF12DC-associated C-type lectin 1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamilymember 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; Dectin1; Dectin-1; DECTIN1CANDF4; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; hDectin-1; lectin-like receptor 1 Clec7a|BG, BGR, Clecsf, Clecsf12, beta-, beta-GR, dectin|C-type lectin domain family 7, member a|C-type lectin domain family 7 member A|C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12|C-type lectin superfamily member 12|DC-associated C-type lectin 1|beta-glucan receptor|dectin-1|dendritic cell-associated C-type lectin 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Clec7a, check out the Clec7a Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Clec7a: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CLEC7A Antibody (A02731)
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