Anti-Collagen VI alpha3 COL6A3 Antibody

Product Name

Anti-Collagen VI alpha3 COL6A3 Antibody

View all Collagen VI alpha 3 Antibodies

SKU/Catalog Number

A02844

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Collagen VI alpha3 COL6A3 Antibody (Catalog# A02844). Tested in IHC-P, IF, ICC, ELISA applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Collagen VI alpha3 COL6A3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02844)

Host

Rabbit

Contents

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A peptide derived from human Collagen VI alpha3. Immunogen sequence location: 2261-2310

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A02844 is reactive to COL6A3 in Human, Mouse

Applications

A02844 is guaranteed for ELISA, IF, IHC-P, ICC Boster Guarantee

Observed Molecular Weight

72 kDa

Calculated molecular weight

343.669kDa

Background of Collagen VI alpha 3

Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry, 1:100 - 1:300
Immunofluorescence, 1:200 - 1:1000
ELISA, 1:40000
Not yet tested in other applications.

Validation Images & Assay Conditions

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Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Collagen VI alpha3 Antibody. The picture on the right is blocked with the synthesized peptide.

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Immunofluorescence analysis of HeLa cells, using Collagen VI alpha3 Antibody. The picture on the right is blocked with the synthesized peptide.

Gene/Protein Information For COL6A3 (Source: Uniprot.org, NCBI)

Alternative Names

Collagen Alpha-3(VI) Chain; Collagen VI, Alpha-3 Polypeptide; collagen, type VI, alpha 3 COL6A3 BTHLM1, DYT27, UCMD1 collagen type VI alpha 3 chain collagen alpha-3(VI) chain|collagen VI, alpha-3 polypeptide|collagen, type VI, alpha 3|epididymis secretory sperm binding protein

For more info on COL6A3, check out the COL6A3 Infographic

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In this infographic, you will see the following information for COL6A3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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