Anti-Connexin 40/GJA5 Antibody
Rabbit IgG polyclonal antibody for Gap junction alpha-5 protein(GJA5) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Anti-Connexin 40/GJA5 Antibody Info At A Glance
|Reactivity:||Human, Mouse, Rat|
|Product Name||Anti-Connexin 40/GJA5 Antibody
See all Connexin 40/GJA5 primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for GJA5 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. GJA5 information: Molecular Weight: 40380 MW; Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.|
|Cite This Product||Anti-Connexin 40/GJA5 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1368)|
|Similar Products From
|Anti-Connexin 40/GJA5 Antibody may replace the following items: sc 20464|sc 20466|sc 28658|sc 365107.|
|Reactivity/Species||Human, Mouse, Rat|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human Connexin 40/GJA5(341-358aa KRRLSKASSKARSDDLSV), identical to the related mouse and rat sequences.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For GJA5 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||2702|
|Species Of This Entry||Human|
|Protein Name||Gap junction alpha-5 protein|
|Alternative Names||Connexin 40/GJA5|alpha 5, 40kD (connexin 40); ATFB11; Connexin 40; connexin-40; CX40; gap junction alpha-5 protein; gap junction protein, alpha 5, 40kDa (connexin 40); gap junction protein, alpha 5, 40kDa; GJA5; MGC11185|
|Post Tranlational Modifications||Phosphoprotein|
|Subcellular Localization||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.|
|Gene Location||1q21.2, on Chromasome 1, gene sequence: NC_000001.11 (147756199..147781127, complement)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For GJA5 (Source: Uniprot.org, NCBI)
|Protein Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|
|Related Diseases||Atrial Fibrillation; Cardiac Fibrillation; Cardiac Arrhythmia; Congenital Heart Disease; Heart Diseases; Congenital Heart Defects; Tetralogy Of Fallot; Heart Block; Neuroblastoma; Cardiovascular Abnormalities; Stenosis; Atresia; Williams Syndrome; Subaortic Stenosis; Cardiac Hypertrophy; Coronary Artery Disease; Hypokinesia; Diabetic Angiopathies; Dysplasia; Cerebrovascular Accident|
|Related Pathways||Transport; Intracellular Transport; Atp-dependent Chromatin Remodeling; Aging; Dna Repair; Pigmentation; Metaphase; Protein Transport; Localization; Cell Differentiation; Pathogenesis; Heart Development; Chromatin Remodeling|
|Background||Connexin proteins oligomerize to form intercellular channels, called gap junctions, through which ions and small molecules move between adjacent cells. Connexin 40(Gap junction alpha-5 protein) is a protein that in humans is encoded by the GJA5 gene.This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described.|
|Scientific References||PMID: 7966354 by Kanter H.L., et al. Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45.|
PMID: 10581143 by Haefliger J.-A., et al. Sporadic cases of dilated cardiomyopathies associated with atrioventricular conduction defects are not linked to mutation within the connexins 40 and 43 genes.
Our Boster Quality Guarantee for Anti-Connexin 40/GJA5 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat
Western blot, 0.1-0.5μg/ml, Mouse, Human, Rat
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Lane 1: Mouse Heart Tissue Lysate
Lane 2: Mouse Heart Tissue Lysate
IHC(P): Rat Cardiac Muscle Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
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- Flow Cytometry Technical Resource Center
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