Anti-CREB/CREB1 Antibody Picoband™

CREB antibody

Boster Bio Anti-CREB/CREB1 Antibody Picoband™ catalog # PB9100. Tested in WB applications. This antibody reacts with Human, Rat. Cited in 1 publication(s).

Product Info Summary

SKU: PB9100
Size: 100μg/vial
Reactive Species: Human, Rat
Host: Rabbit
Application: WB

Product Name

Anti-CREB/CREB1 Antibody Picoband™

View all CREB Antibodies

SKU/Catalog Number

PB9100

Size

100μg/vial

Form

Lyophilized

Description

Boster Bio Anti-CREB/CREB1 Antibody Picoband™ catalog # PB9100. Tested in WB applications. This antibody reacts with Human, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CREB/CREB1 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9100)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Immunogen

E.coli-derived human CREB recombinant protein (Position: M1-T177). Human CREB shares 99% and 98% amino acid (aa) sequences identity with mouse and rat CREB, respectively.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross Reactivity

No cross reactivity with other proteins

Reactive Species

PB9100 is reactive to CREB1 in Human, Rat

Applications

PB9100 is guaranteed for WB Boster Guarantee

Background of CREB

CREB1, also known as cAMP responsive element binding protein 1, is a protein that in humans is encoded by the CREB1 gene. It is mapped to 2q33.3. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription. This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Rat

Validation Images & Assay Conditions

Gene/Protein Information For CREB1 (Source: Uniprot.Org, NCBI)

Uniprot ID

P16220

Gene ID

1385

Gene Name

CREB1

Full Name

Cyclic AMP-responsive element-binding protein 1

Weight

36.688kDa

Superfamily

bZIP family

Alternative Names

active transcription factor CREB; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB1; CREB-1; cyclic AMP-responsive element-binding protein 1; MGC9284; pCREB; transactivator protein CREB1 CREB, CREB-1 cAMP responsive element binding protein 1 cyclic AMP-responsive element-binding protein 1|active transcription factor CREB|cAMP-response element-binding protein-1|cyclic adenosine 3,5-monophosphate response element binding protein|cyclic adenosine 3,5-monophosphate response element-binding protein CREB|transactivator protein

*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".

For more info on CREB1, check out the CREB1 Infographic

CREB1 infographic

We have 30,000+ of these available, one for each gene! check them out.

In this infographic you will see the following information for CREB1: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]

PB9100 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn?s disease

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4 Customer Q&As for Anti-CREB/CREB1 Antibody Picoband™

Question

I am interested in using your anti-CREB/CREB1 antibody for secretory granule organization studies. Has this antibody been tested with western blotting on brain tissue? We would like to see some validation images before ordering.

Verified Customer

Verified customer

Asked: 2020-04-24

Answer

Thank you for your inquiry. This PB9100 anti-CREB/CREB1 antibody is validated on rat thymus tissue, tissue lysate, brain tissue, ht1080 whole cell lysate. It is guaranteed to work for WB in human, rat. Our Boster guarantee will cover your intended experiment even if the sample type has not been be directly tested.

Boster Scientific Support

Answered: 2020-04-24

Question

We have been able to see staining in rat testis. What should we do? Is anti-CREB/CREB1 antibody supposed to stain testis positively?

Verified Customer

Verified customer

Asked: 2020-04-03

Answer

From what I have seen in literature testis does express CREB1. From what I have seen in Uniprot.org, CREB1 is expressed in lung, testis, eye, embryonic kidney, cervix carcinoma, leukemic t-cell, cervix carcinoma erythroleukemia, liver, among other tissues. Regarding which tissues have CREB1 expression, here are a few articles citing expression in various tissues:
Cervix carcinoma, Pubmed ID: 18669648
Cervix carcinoma, and Erythroleukemia, Pubmed ID: 23186163
Embryonic kidney, Pubmed ID: 17525332
Eye, Pubmed ID: 15489334
Leukemic T-cell, Pubmed ID: 19690332
Liver, Pubmed ID: 24275569
Testis, Pubmed ID: 15579595

Boster Scientific Support

Answered: 2020-04-03

Question

Our team were well pleased with the WB result of your anti-CREB/CREB1 antibody. However we have been able to see positive staining in lung nucleus using this antibody. Is that expected? Could you tell me where is CREB1 supposed to be expressed?

Verified Customer

Verified customer

Asked: 2019-11-05

Answer

Based on literature, lung does express CREB1. Generally CREB1 expresses in nucleus. Regarding which tissues have CREB1 expression, here are a few articles citing expression in various tissues:
Cervix carcinoma, Pubmed ID: 18669648
Cervix carcinoma, and Erythroleukemia, Pubmed ID: 23186163
Embryonic kidney, Pubmed ID: 17525332
Eye, Pubmed ID: 15489334
Leukemic T-cell, Pubmed ID: 19690332
Liver, Pubmed ID: 24275569
Testis, Pubmed ID: 15579595

Boster Scientific Support

Answered: 2019-11-05

Question

We are currently using anti-CREB/CREB1 antibody PB9100 for human tissue, and we are happy with the WB results. The species of reactivity given in the datasheet says human, rat. Is it likely that the antibody can work on bovine tissues as well?

Verified Customer

Verified customer

Asked: 2017-09-13

Answer

The anti-CREB/CREB1 antibody (PB9100) has not been validated for cross reactivity specifically with bovine tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in bovine you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2017-09-13

Size

Total: $315

SKU:PB9100

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Ships directly to USA and Canada. For other regions, visit our distributors page

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PB9100
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$315.00

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