Product Info Summary
SKU: | A02703 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Cyclin-T1 CCNT1 Antibody
SKU/Catalog Number
A02703
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Cyclin-T1 CCNT1 Antibody (Catalog # A02703). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CCNT1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-Cyclin-T1 CCNT1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02703)
Host
Rabbit
Contents
CCNT1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
SK7
Isotype
IgG
Immunogen
Rabbit polyclonal CCNT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human CCNT1. The immunogen is located within the last 50 amino acids of CCNT1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Minor, lower molecular weight bands may represent alternately spliced forms.
Reactive Species
A02703 is reactive to CCNT1 in Human, Mouse, Rat
Applications
A02703 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
80.685kDa
Background of Cyclin T1
Cyclins function as regulators of CDK kinases and exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin-T1 protein (CCNT1) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. CCNT1 tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing CCNT1 and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. CCNT1 and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CCNT1 antibody can be used for detection of CCNT1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CCNT1 in rat brain tissue lysate with CCNT1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of CCNT1 in rat brain tissue with CCNT1 antibody at 2.5 μg/ml.
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Immunofluorescence of CCNT1 in rat brain tissue with CCNT1 antibody at 20 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For CCNT1 (Source: Uniprot.org, NCBI)
Gene Name
CCNT1
Full Name
Cyclin-T1
Weight
80.685kDa
Superfamily
cyclin family
Alternative Names
CCNT; CCNT1; CCNTcyclin-T; CDK9-associated C-type protein; cyclin C-related protein; cyclin T1; cyclin T1b; Cyclin-T; cyclin-T1; CYCT1; HIVE1; human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1; Human immunodeficiency virus-1 expression; subunit of positive elongation transcription factor b CCNT1 CCNT, CYCT1, HIVE1 cyclin T1 cyclin-T1|CDK9-associated C-type protein|MLLT10/CCNT1 fusion|cyclin C-related protein|human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CCNT1, check out the CCNT1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CCNT1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Cyclin-T1 CCNT1 Antibody (A02703)
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No publications found for A02703
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