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Cyclin-T1 Antibodies
AND CCNT1 ELISA kits, Cyclin-T1 Proteins
Many biological assays use antibodies to detect Cyclin-T1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cyclin-T1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cyclin-T1 antibodies...
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CCNT1 Infographic by Boster Bio
All CCNT1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # PB9990
100 μg/vial
Cat # PB9990
100 μg/vial
Human, Monkey
Flow Cytometry, WB
$370
Cat # M02703
100 μg/vial
Cat # M02703
100 μg/vial
CCNT1 Overview
Facts about Cyclin-T1.
Cyclin-T1 (CCNT1)
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is suggested to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). .
Gene Information
| Human | |
|---|---|
| Gene Name: | CCNT1 |
| Uniprot: | O60563 |
| Entrez: | 904 |
Family
| Belongs to: |
|---|
| cyclin family |
Alternative Names
CCNT; CCNT1; CCNTcyclin-T; CDK9-associated C-type protein; cyclin C-related protein; cyclin T1; cyclin T1b; Cyclin-T; cyclin-T1; CYCT1; HIVE1; human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1; Human immunodeficiency virus-1 expression; subunit of positive elongation transcription factor b
Molecular Weight
Mass (kDA):
80.685 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.11-q13.12 |
| Sequence: | 12; NC_000012.12 (48688458..48716707, complement) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Nucleus.
Diseases
- Hiv Infections
- Immunologic Deficiency Syndromes
- Acquired Immunodeficiency Syndrome
- Hypertrophy
- Cardiac Hypertrophy
- Cytomegalovirus Infections
- Anemia
- Equine Infectious Anemia
- Cell Transformation, Neoplastic
- Malignant Neoplasms
- Neoplasms
Interacting Proteins
- AFF4
- CDK9
- HEXIM1
Pathways
- Viral Replication
- Localization
- Pathogenesis
- Cell Cycle
- Viral Transcription
- Macrophage Differentiation
- Cell Growth
- Proteolysis
- Reverse Transcription
- Nuclear Import
- Monocyte Differentiation
- Chromatin Remodeling
- Hyperphosphorylation
PTMs
- Phosphorylation
- Acetylation
- Deacetylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCNT1
bosterbio.com/bosterbio-gene-info-cards/CCNT1
References
PMID: 9491887 by Wei P., et al. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.
PMID: 9499409 by Peng J.-M., et al. Identification of multiple cyclin subunits of human P-TEFb.