Product Info Summary
SKU: | A00439 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Daxx Antibody
SKU/Catalog Number
A00439
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Daxx Antibody (Catalog # A00439). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
Daxx antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Daxx Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00439)
Host
Rabbit
Contents
Daxx Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Daxx antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human Daxx. The immunogen is located within the last 50 amino acids of Daxx.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
ALSFTD antibody is human, mouse and rat reactive. At least two isoforms are known to exist.
Reactive Species
A00439 is reactive to DAXX in Human, Mouse
Applications
A00439 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
81.373kDa
Background of DAXX
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Daxx antibody can be used for detection of Daxx by Western blot at 1 μg/mL. A 120 kDa major band can be detected. Antibody can also be used for immunocytochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Daxx in 293 total cell lysate with Dax antibody at 1 mg/mL.
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Immunocytochemistry of DAXX in HeLa cells with DAXX antibody at 10 μg/mL.
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Immunofluorescence of Daxx in Hela cells with Daxx antibody at 20 μg/mL.
Green: Daxx Antibody (A00439)
Blue: DAPI staining
Protein Target Info & Infographic
Gene/Protein Information For DAXX (Source: Uniprot.org, NCBI)
Gene Name
DAXX
Full Name
Death domain-associated protein 6
Weight
81.373kDa
Superfamily
DAXX family
Alternative Names
BING2; CENP-C binding protein; DAP6; DAP6MGC126245; Daxx; death domain-associated protein 6; death-associated protein 6; death-domain associated protein; EAP1; ETS1-associated protein 1; Fas death domain-associated protein; Fas-binding protein; hDaxx; MGC126246 DAXX BING2, DAP6, EAP1, SMIM40 death domain associated protein death domain-associated protein 6|CENP-C binding protein|ETS1-associated protein 1|Fas-binding protein|death-associated protein 6|fas death domain-associated protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DAXX, check out the DAXX Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DAXX: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Daxx Antibody (A00439)
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No publications found for A00439
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Customer Reviews
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