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Product Info Summary
| SKU: | MA1037 |
|---|---|
| Size: | 100μg/vial |
| Reactive Species: | Human, Mouse, Rabbit, Rat |
| Host: | Mouse |
| Application: | IHC, WB |
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Product info
Product Name
Anti-Dystrophin Dmd Antibody (Monoclonal, MANDYS8)
View all Dystrophin Antibodies
SKU/Catalog Number
MA1037
Size
100μg/vial
Form
Lyophilized
Description
Boster Bio Anti-Dystrophin Dmd Antibody (Monoclonal, MANDYS8) catalog # MA1037. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rabbit, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Dystrophin Dmd Antibody (Monoclonal, MANDYS8) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1037)
Host
Mouse
Contents
Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Clonality
Monoclonal
Clone Number
MANDYS8
Isotype
Mouse IgG2b
Immunogen
Recombinant human dystrophin fragment.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross Reactivity
No cross reactivity with other proteins
Reactive Species
MA1037 is reactive to Dmd in Human, Mouse, Rabbit, Rat
Applications
MA1037 is guaranteed for IHC, WB Boster Guarantee
Background of Dystrophin
Dystrophin (DMD) gene has 79 exons spanning at least 2,300 kb (2.3 Mb). The C terminus of the dystrophin protein is encoded by a highly conserved, alternatively spliced region of the gene. beta-dystroglycan binding activity is expressed by the dystrophin fragment spanning amino acids 3026-3345 containing the ZZ domain. DMD transcript is formed by at least 60 exons; the first half of the transcript is formed by a minimum of 33 exons spanning nearly 1000 kb, and the remaining portion has at least 27 exons that may spread over a similar distance. Dystrophin gene is expressed at a higher level in primary cultures of neuronal cells than in astro-glial cells derived from adult mouse brain. overexpression of dystrophin prevents the development of the abnormal mechanical properties associated with dystrophic muscle without causing deleterious side effects.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists world wide.
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Assay dilution & Images
Reconsitution
Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.
Immunohistochemistry (Paraffin-embedded Section), 2-4μg/ml, Human, mouse, rabbit, rat, By Heat
Western blot, 1-2μg/ml, Human, mouse, rabbit, rat
Validation Images & Assay Conditions
Click image to see more details
Boster Kit Box
Protein Target Info & Infographic
Gene/Protein Information For Dmd (Source: Uniprot.Org, NCBI)
Uniprot ID
P11530
Gene ID
24907
Gene Name
Dmd
Full Name
Dystrophin
Weight
425.828kDa
Alternative Names
BMDDXS272; CMD3B; DXS142; DXS164; DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; dystrophin (muscular dystrophy, Duchenne and Becker types), includes DXS142; dystrophin Dmd|DNADMD1|dystrophin|dystrophin|apodystrophin-3|apodystrophin-I|dystrophin, muscular dystrophy|dystrophin-related
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".For more info on Dmd, check out the Dmd Infographic
We have 30,000+ of these available, one for each gene! check them out.
In this infographic you will see the following information for Dmd: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected]
Specific Publications For Anti-Dystrophin Dmd Antibody (Monoclonal, MANDYS8) (MA1037)
No publications found for MA1037
*Do you have publications using this product? Share with us and receive a reward. Ask us for more details.
Recommended Resources
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- Boster's Pathways Library
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Customer Reviews
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Customer Q&As
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Find answers in Q&As, reviews.
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6 Customer Q&As for Anti-Dystrophin Dmd Antibody (Monoclonal, MANDYS8)
Question
Will this cross react to zebrafish? Keyword: cross reaction
Verified Customer
Verified customer
Asked: 2020-05-07
Answer
The immunogen of MA1037 shares very low homology with zebrafish, it will not cross react with zebrafish samples.
Boster Scientific Support
Answered: 2020-05-07
Question
Is this MA1037 anti-Dystrophin antibody (Monoclonal, MANDYS8) reactive to the isotypes of DMD?
Verified Customer
Verified customer
Asked: 2019-10-29
Answer
The immunogen of MA1037 anti-Dystrophin antibody (Monoclonal, MANDYS8) is Recombinant human dystrophin fragment. Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?
Boster Scientific Support
Answered: 2019-10-29
Question
My question regarding product MA1037, anti-Dystrophin antibody (Monoclonal, MANDYS8). I was wondering if it would be possible to conjugate this antibody with biotin. I would need it to be without BSA or sodium azide. I am planning on using a buffer exchange of sodium azide with PBS only. Would there be problems for me to conjugate the antibody and store it in -20 degrees in small aliquots?
M. Carter
Verified customer
Asked: 2019-09-17
Answer
It is not recommended storing this antibody with PBS buffer only in -20 degrees. If you want to store it in -20 degrees it is best to add some cryoprotectant like glycerol. If you want carrier free MA1037 anti-Dystrophin antibody (Monoclonal, MANDYS8), we can provide it to you in a special formula with trehalose and/or glycerol. These molecules will not interfere with conjugation chemistry and provide a good level of protection for the antibody from degradation. Please be sure to specify this in your purchase order.
Boster Scientific Support
Answered: 2019-09-17
Question
Do you have a BSA free version of anti-Dystrophin antibody (Monoclonal, MANDYS8) MA1037 available?
Verified Customer
Verified customer
Asked: 2019-08-01
Answer
I appreciate your recent telephone inquiry. I can confirm that some lots of this anti-Dystrophin antibody (Monoclonal, MANDYS8) MA1037 are BSA free. For now, these lots are available and we can make a BSA free formula for you free of charge. It will take 3 extra days to prepare. If you require this antibody BSA free again in future, please do not hesitate to contact me and I will be pleased to check which lots we have in stock that are BSA free.
Boster Scientific Support
Answered: 2019-08-01
Question
I was wanting to use your anti-Dystrophin antibody (Monoclonal, MANDYS8) for IHC for rat brain on frozen tissues, but I want to know if it has been validated for this particular application. Has this antibody been validated and is this antibody a good choice for rat brain identification?
R. Jha
Verified customer
Asked: 2015-11-02
Answer
You can see on the product datasheet, MA1037 anti-Dystrophin antibody (Monoclonal, MANDYS8) has been validated for IHC, WB on human, mouse, rabbit, rat tissues. We have an innovator award program that if you test this antibody and show it works in rat brain in IHC-frozen, you can get your next antibody for free.
Boster Scientific Support
Answered: 2015-11-02
Question
I see that the anti-Dystrophin antibody (Monoclonal, MANDYS8) MA1037 works with IHC, what is the protocol used to produce the result images on the product page?
K. Thomas
Verified customer
Asked: 2015-03-16
Answer
You can find protocols for IHC on the "support/technical resources" section of our navigation menu. If you have any further questions, please send an email to [email protected]
Boster Scientific Support
Answered: 2015-03-16
