Anti-Dystrophin Dmd Antibody (Monoclonal, MANDYS8)
Mouse IgG monoclonal antibody for Dystrophin, dystrophin (DMD) detection. Tested with WB, IHC-P in Human;mouse;rat;rabbit. No cross reactivity with other proteins.
Anti-Dystrophin Dmd Antibody (Monoclonal, MANDYS8) Info At A Glance
|Reactivity:||Human, Mouse, Rabbit, Rat|
|Product Name||Anti-Dystrophin Dmd Antibody (Monoclonal, MANDYS8)
See all Dystrophin primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Monoclonal clone# G2 antibody for DYSTROPHIN/DMD detection. Host: Mouse.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. DYSTROPHIN/DMD information: Molecular Weight: 425828 MW; Subcellular Localization: Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell junction, synapse, postsynaptic cell membrane . In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs). In adult muscle, NMJ localization depends upon ANK2 presence, but not in newborn animals; Tissue Specificity: Strongly expressed in skeletal muscle and weak expression observed in newborn brain which increases in adult brain.|
|Cite This Product||Anti-Dystrophin Dmd Antibody (Monoclonal, MANDYS8) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1037)|
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|Anti-Dystrophin Dmd Antibody (Monoclonal, MANDYS8) may replace the following items: sc 15376|sc 22027|sc 292163|sc 32792|sc 33697|sc 33698|sc 365954|sc 47760|sc 58754|sc 73592|sc 7459|sc 7461|sc 7462.|
|Reactivity/Species||Human, Mouse, Rabbit, Rat|
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (EK1001) for Western blot, and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (SV0001-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||Recombinant human dystrophin fragment.|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For Dmd (Source: Uniprot.org, NCBI)
|NCBI Gene Id||24907|
|Species Of This Entry||Rat|
|Alternative Names||Dystrophin|BMDDXS272; CMD3B; DXS142; DXS164; DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; dystrophin (muscular dystrophy, Duchenne and Becker types), includes DXS142; dystrophin|
|Post Tranlational Modifications||Methylation; Oxidation; Phosphorylation; Cleavage; Demethylation; Phosphorothioation; Glycosylation; Reduction; Nitration; Biotinylation; Deacetylation; Acetylation|
|Gene Location||Xq21, on Chromasome X, gene sequence:|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For Dmd (Source: Uniprot.org, NCBI)
|Protein Function||Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin- associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission.|
|Research Areas||Cell Biology; Cellular Markers|
|Related Diseases||Muscular Dystrophy; Dystrophy; Muscular Dystrophy, Duchenne; Becker Muscular Dystrophy; Muscular Dystrophy, Animal; Myopathy; Neuromuscular Diseases; Cardiomyopathies; Weakness; Fibrosis; Muscular Atrophy; Muscle Weakness; Atrophy; Sclerosis; Heart Failure; Muscle Degeneration; Hereditary Diseases; Muscular Dystrophies, Limb-girdle; Cardiomyopathy, Dilated|
|Related Pathways||Regeneration; Localization; Pathogenesis; Methylation; Translation; Immune Response; Dna Methylation; Transport; Fermentation; Excretion; Muscle Atrophy; Cell Death; Reverse Transcription; Aging; Inflammatory Response; Sex Determination; Spermatogenesis; Muscle Hypertrophy; Muscle Contraction; Interphase|
|Background||Dystrophin(DMD) gene has 79 exons spanning at least 2,300 kb(2.3 Mb). The C terminus of the dystrophin protein is encoded by a highly conserved, alternatively spliced region of the gene. beta-dystroglycan binding activity is expressed by the dystrophin fragment spanning amino acids 3026-3345 containing the ZZ domain. DMD transcript is formed by at least 60 exons; the first half of the transcript is formed by a minimum of 33 exons spanning nearly 1000 kb, and the remaining portion has at least 27 exons that may spread over a similar distance. Dystrophin gene is expressed at a higher level in primary cultures of neuronal cells than in astro-glial cells derived from adult mouse brain. overexpression of dystrophin prevents the development of the abnormal mechanical properties associated with dystrophic muscle without causing deleterious side effects.|
|Scientific References||PMID: 3340214 by Nudel U., et al. Expression of the putative Duchenne muscular dystrophy gene in differentiated myogenic cell cultures and in the brain.|
Our Boster Quality Guarantee for Anti-Dystrophin Dmd Antibody (Monoclonal, MANDYS8) covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 2-4μg/ml, Human, mouse, rabbit, rat, By Heat
Western blot, 1-2μg/ml, Human, mouse, rabbit, rat
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
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- Flow Cytometry Technical Resource Center
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