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Product Info Summary
| SKU: | A11563 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Chicken |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-ECRG2 SPINK7 Antibody
SKU/Catalog Number
A11563
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-ECRG2 SPINK7 Antibody (Catalog # A11563). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
ECRG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-ECRG2 SPINK7 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A11563)
Host
Chicken
Contents
ECRG2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgY
Immunogen
ECRG2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG2. The immunogen is located within the last 50 amino acids of ECRG2.
Cross-reactivity
ECRG2 antibody is predicted to not cross-react with other ECRG family members
Reactive Species
A11563 is reactive to SPINK7 in Human, Mouse, Rat
Calculated molecular weight
9.2 kDa
Background of SPINK7
The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A11563 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ECRG2 antibody can be used for detection of ECRG2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of ECRG2 in A-20 cell lysate with ECRG2 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.
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Immunohistochemistry of ECRG2 in rat lung tissue with ECRG2 antibody at 5 μg/mL.
Specific Publications For Anti-ECRG2 SPINK7 Antibody (A11563)
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