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Product Info Summary
| SKU: | A00190-1 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | WB |
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Product info
Product Name
Anti-Endoribonuclease Dicer DICER1 Antibody
SKU/Catalog Number
A00190-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Endoribonuclease Dicer DICER1 Antibody catalog # A00190-1. Tested in WB applications. This antibody reacts with Human,Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Endoribonuclease Dicer DICER1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00190-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human Flt-3 around the phosphorylation site of Y969.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A00190-1 is reactive to DICER1 in Human, Mouse
Applications
A00190-1 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
218.682kDa
Background of Dicer
FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Sekine S et,al. (2008) J Immunol. ;180(12):8126-34
Pratz K et,al. (2008) Leuk Lymphoma. 2008 ;49(5):852-63.
Al Shaer L et,al. (2008) Br J Haematol. 141(4):483-93.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:1000
Validation Images & Assay Conditions
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Figure 1. Western blotting validation for Anti-Endoribonuclease Dicer DICER1 Antibody A00190-1
Western blot analysis of extracts of various cellsProtein Target Info & Infographic
Gene/Protein Information For DICER1 (Source: Uniprot.org, NCBI)
Gene Name
DICER1
Full Name
Endoribonuclease Dicer
Weight
218.682kDa
Superfamily
helicase family
Alternative Names
DCR1; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease type III; Dicer; Dicer1, Dcr-1 homolog (Drosophila); EC 3.1.26; EC 3.1.26.-; EC 3.1.26.3; Helicase MOI; Helicase with RNase motif; helicase-moi; HERNADicer1, Dcr-1 homolog; K12H4.8-LIKE; KIAA0928endoribonuclease Dicer DICER1 DCR1, Dicer, Dicer1e, GLOW, HERNA, K12H4.8-LIKE, MNG1, RMSE2 dicer 1, ribonuclease III endoribonuclease Dicer|Dicer1, Dcr-1 homolog|dicer 1, double-stranded RNA-specific endoribonuclease|dicer 1, ribonuclease type III|helicase MOI|helicase with RNAse motif
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DICER1, check out the DICER1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DICER1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Endoribonuclease Dicer DICER1 Antibody (A00190-1)
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No publications found for A00190-1
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