Anti-Episialin, EMA MUC1 Antibody (Monoclonal, GP1.4)

Product Name

Anti-Episialin, EMA MUC1 Antibody (Monoclonal, GP1.4)

View all MUC1 Antibodies

SKU/Catalog Number

MA1039
BM0042 is an alternative SKU for this antibody, used in previous lots.

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Episialin, EMA MUC1 Antibody (Monoclonal, GP1.4) catalog # MA1039. Tested in IHC applications. This antibody reacts with Human.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Episialin, EMA MUC1 Antibody (Monoclonal, GP1.4) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1039)

Host

Mouse

Contents

Mouse IgG in stabilizing components, 1.2% sodium acetate and 0.01mg NaN3.

Clonality

Monoclonal

Clone Number

GP1.4

Isotype

Mouse IgG1

Immunogen

Human milk fat globule membranes.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

MA1039 is reactive to MUC1 in Human

Calculated molecular weight

122.1 kDa

Background of MUC1

MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type I transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

MA1039 is guaranteed for IHC Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 2-4μg/ml, Human
Immunohistochemistry (Frozen Section), 2-4μg/ml, Human

Positive Control

IHC: Human Mammary Cancer Tissue, Human Intestinal Cancer Tissue, Human Lung Cancer Tissue

Validation Images & Assay Conditions

See full target information MUC1

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