Anti-Fatty Acid Binding Protein 5/FABP5 Antibody
Rabbit IgG polyclonal antibody for Fatty acid-binding protein, epidermal(FABP5) detection. Tested with WB, IHC-P in Human.
Anti-Fatty Acid Binding Protein 5/FABP5 Antibody Info At A Glance
Killer Cell Lectin-like Receptor Subfamily G, Member 1 (KLRG1) is a member of the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Natural killer (NK) cells are lymphocytes which mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells can also regulate specific humoral and cell-mediated immunity. The cell surface expression of KLRG1 is up-regulated by MHC class I molecules expression.
|Product Name||Anti-Fatty Acid Binding Protein 5/FABP5 Antibody
See all FABP5/E-FABP primary antibodies, ELISA kits and proteins
|Storage & Handling||At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.Avoid repeated freezing and thawing.|
|Description||Polyclonal antibody for E FABP/FABP5 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. E FABP/FABP5 information: Molecular Weight: 15164 MW; Subcellular Localization: Cytoplasm; Tissue Specificity: Keratinocytes; highly expressed in psoriatic skin.|
|Cite This Product||Anti-Fatty Acid Binding Protein 5/FABP5 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1475)|
|Similar Products From
|Anti-Fatty Acid Binding Protein 5/FABP5 Antibody may replace the following items: sc 16060|sc 365166|sc 365236|sc 373788|sc 50379.|
*This antibody is predicted to react with the above species based on antigen sequence similarities. Our Boster Guarantee covers the use of this product with the above species.
*Our Boster Guarantee covers the use of this product in the above tested applications.
*Innovating Scientists reward: if you test this antibody on a species or application not listed above and share with us your results, we will provide you a full credit to purchase Boster products.
|Related Products||Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
*Blocking peptide can be purchased at $50. Contact us for more information.
**Boster also offers various secondary antibodies for Immunoflourescecne and IHC. Take advantage of the buy 1 primary antibody get 1 secondary antibody for free promotion all year round.
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human Fatty Acid Binding Protein 5(2-16aa ATVQQLEGRWRLVDS).|
|Cross Reactivity||No cross reactivity with other proteins|
Gene/Protein Basic Information For FABP5 (Source: Uniprot.org, NCBI)
|NCBI Gene Id||2171|
|Species Of This Entry||Human|
|Protein Name||Fatty acid-binding protein 5|
|Alternative Names||FABP5/E-FABP|EFABP; E-FABP; E-FABPPAFABP; FABP5; fatty acid binding protein 5 (psoriasis-associated); Fatty acid-binding protein 5; PA-FABPepidermal; Psoriasis-associated fatty acid-binding protein homolog|
|Post Tranlational Modifications||Phosphorylation; Oxidation; Acetylation; Methylation; Cleavage; Carboxylation; Biotinylation; Reduction; Phosphorothioation; Glycosylation; Ubiquitination; Iodination|
|Subcellular Localization||Cytoplasm. Nucleus. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Secreted. Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity).|
|Gene Location||8q21.13, on Chromasome 8, gene sequence: NC_000008.11 (81280536..81284775)|
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
Ontology For FABP5 (Source: Uniprot.org, NCBI)
|Protein Function||Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987).|
|Tissue Specificity||Keratinocytes; highly expressed in psoriatic skin.|
|Related Diseases||Fatty Liver; Neoplasms; Malignant Neoplasms; Obesity; Carcinoma; Insulin Resistance; Inflammation; Diabetes Mellitus; Malignant Squamous Cell Neoplasm; Atherosclerosis; Insulin Sensitivity; Diabetes Mellitus, Non-insulin-dependent; Nervousness; Psoriasis; Cell Transformation, Neoplastic; Malignant Paraganglionic Neoplasm; Neoplasm Metastasis; Cell Invasion; Intestinal Schistosomiasis; Skin Neoplasms|
|Related Pathways||Transport; Localization; Cell Growth; Lipid Binding; Secretion; Cell Differentiation; Cell Proliferation; Fatty Acid Transport; Pathogenesis; Cytokine Production; Regulation Of Gene Expression; Cellular Localization; Immune Response; Neurogenesis; Fatty Acid Oxidation; Rna Interference; Cell Cycle; Keratinocyte Differentiation; Phagocytosis; Lipid Homeostasis|
|Background||FABP5, Fatty acid-binding protein, epidermal, is a protein that in humans is encoded by the FABP5 gene. This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. It is mapped to 8q21.13. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is though that FABPs roles include fatty acid uptake, transport, and metabolism.|
|Scientific References||PMID: 1512466 by Madsen P.S., et al. Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins.|
PMID: 8092987 by Siegenthaler G., et al. Purification and characterization of the human epidermal fatty acid- binding protein: localization during epidermal cell differentiation in vivo and in vitro.
Our Boster Quality Guarantee for Anti-Fatty Acid Binding Protein 5/FABP5 Antibody covers its use in the following applications.Immunohistochemistry(Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
*The recommended dilution ratios/concentrations are for reference only and optimal dilutions/concentrations should be determined by the end user.
All lanes: Anti Fatty Acid Binding Protein 5 (PA1475) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: HEPG2 Whole Cell Lysate at 40ug
Predicted bind size: 15KD
Observed bind size: 15KD
IHC(P): Human Intestinal Cancer Tissue
Boster provides comprehensive technical information for WB, IHC/IF/ICC, Flow Cytometry sample preparation protocols, assay protocols, troubleshooting tips and assay optimization tips.
- Western Blottting Resource Center
- Immunohistochemistry Resource Center
- Flow Cytometry Technical Resource Center
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Note: sample size takes longer to process, average 5-7 days.
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