Anti-FIG4 Antibody

Product Name

Anti-FIG4 Antibody

View all FIG4 Antibodies

SKU/Catalog Number

A04403

Size

100μl

Form

Liquid

Description

Boster Bio Anti-FIG4 Antibody catalog # A04403. Tested in WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-FIG4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04403)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

3F8

Isotype

IgG

Immunogen

Synthesized peptide derived from Human FIG4 at AA range: 341-390.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A04403 is reactive to FIG4 in Human, Mouse

Applications

A04403 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

103.635kDa

Background of FIG4

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript rTS alpha vary inversely when cell-growth progresses from late-log to plateau phase. Diseases associated with Thymidylate synthase include Rectal Neoplasm and Dihydropyrimidine Dehydrogenase Deficiency. Anti-Thymidylate synthase is useful for researchers interested in Circadian Rhythm, Metabolism and cell cycle research.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-2000

Validation Images & Assay Conditions

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Western Blot analysis of 1) mouse liver, 2) HeLa, 3) mouse brain cells using primary antibody diluted at 1: 1000 (4℃ overnight) . Secondary antibody: Goat Anti-rabbit IgG IRDye 800 (diluted at 1: 5000, 25℃, 1 hour).

Gene/Protein Information For FIG4 (Source: Uniprot.org, NCBI)

Alternative Names

ALS11polyphosphoinositide phosphatase; CMT4J; dJ249I4.1; EC 3.1.3; EC 3.1.3.-; EC 3.1.3.36; FIG4 homolog (S. cerevisiae); FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae); hSac3; KIAA0274FIG4 homolog, SAC domain containing lipid phosphatase; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; Sac domain-containing inositol phosphatase 3; SAC domain-containing protein 3; SAC3FIG4 homolog, SAC1 domain containing lipid phosphatase FIG4 ALS11, BTOP, CMT4J, KIAA0274, SAC3, YVS, dJ249I4.1 FIG4 phosphoinositide 5-phosphatase polyphosphoinositide phosphatase|FIG4 homolog, SAC domain containing lipid phosphatase|FIG4 homolog, SAC1 domain containing lipid phosphatase|FIG4 homolog, SAC1 lipid phosphatase domain containing|SAC domain-containing protein 3|Sac domain-containing inositol phosphatase 3|phosphatidylinositol 3,5-bisphosphate 5-phosphatase

For more info on FIG4, check out the FIG4 Infographic

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In this infographic, you will see the following information for FIG4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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