Product Info Summary
SKU: | A10447 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-FK506-binding protein 15 FKBP15 Antibody
SKU/Catalog Number
A10447
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-FK506-binding protein 15 FKBP15 Antibody (Catalog # A10447). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
FKBP15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-FK506-binding protein 15 FKBP15 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10447)
Host
Rabbit
Contents
FKBP15 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Clone Number
SK7
Isotype
IgG
Immunogen
FKBP15 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human FKBP15. The immunogen is located within amino acids 30 - 80 of FKBP15.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
This antibody is specific for RKHD3 and will not recognize the other RKHD3 family of proteins.
Reactive Species
A10447 is reactive to FKBP15 in Human, Mouse, Rat
Applications
A10447 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Observed Molecular Weight
68 kDa
Calculated molecular weight
133.63kDa
Background of FKBP15
FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
FKBP15 antibody can be used for detection of FKBP15 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of FKBP15 in 3T3 cell lysate with FKBP15 antibody at 1 μg/mL.
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Immunohistochemistry of FKBP15 in mouse brain tissue with FKBP15 antibody at 2.5 μg/mL.
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Immunofluorescence of FKBP15 in mouse brain tissue with FKBP15 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For FKBP15 (Source: Uniprot.org, NCBI)
Gene Name
FKBP15
Full Name
FK506-binding protein 15
Weight
133.63kDa
Superfamily
FKBP-type PPIase family
Alternative Names
FK506 binding protein 15, 133kDa; FK506-binding protein 133kDa; FK506-binding protein 15; FKBP133; FKBP-133; FKBP-15,133 kDa FKBP; PPP1R76,133 kDa FK506-binding protein; regulatory subunit 76; WAFL FKBP15 FKBP133, KIAA0674, PPP1R76 FKBP prolyl isomerase family member 15 FK506-binding protein 15|133 kDa FK506-binding protein|133 kDa FKBP|FK506 binding protein 15, 133kDa|FK506-binding protein 133kDa|FKBP prolyl isomerase 15|FKBP-133|FKBP-15|WAFL|WASP and FKBP-like protein|protein phosphatase 1, regulatory subunit 76
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FKBP15, check out the FKBP15 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FKBP15: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-FK506-binding protein 15 FKBP15 Antibody (A10447)
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