Product Info Summary
SKU: | A00011-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human |
Host: | Rabbit |
Application: | Flow Cytometry, ICC |
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Product info
Product Name
Anti-Forkhead box protein P3 FOXP3 Antibody
SKU/Catalog Number
A00011-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Forkhead box protein P3 FOXP3 Antibody catalog # A00011-1. Tested in ICC,Flow Cytometry applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Forkhead box protein P3 FOXP3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00011-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Clone Number
PI9-17
Isotype
IgG
Immunogen
Synthesized peptide derived from human Neu around the phosphorylation site of Y1221/Y1222.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Weakly cross-reacts with dog p53.
Reactive Species
A00011-1 is reactive to Foxp3 in Human
Applications
A00011-1 is guaranteed for Flow Cytometry, ICC Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
47.346kDa
Background of Foxp3
Anti-Glycogen Synthase 1 pS641 antibody is validated by IHC, Western Blot and ELISA. Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units. Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000. GS is subject to regulation through both allosteric and covalent modification and occurs in two forms: the phosphorylated inactive form, and the dephosphorylated active form. GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3 that mainly functions to phosphorylate muscle glycogen synthase. This antibody is specific for the phosphorylated form of GS at S641. Phosphorylation of GS at S641 has been associated with Antiphospholipid Antibody Syndrome.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ICC: 1:50-1:200
FC: 1:50-1:100
Validation Images & Assay Conditions
Click image to see more details
Figure 1. Immunocytochemistry staining of FOXP3 using Anti-Forkhead box protein P3 FOXP3 Antibody (A00011-1).
ICC staining FOXP3 in MCF-7 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehydeClick image to see more details
Figure 2. Immunocytochemistry staining of FOXP3 using Anti-Forkhead box protein P3 FOXP3 Antibody (A00011-1).
ICC staining FOXP3 in 293T cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehydeProtein Target Info & Infographic
Gene/Protein Information For Foxp3 (Source: Uniprot.org, NCBI)
Gene Name
Foxp3
Full Name
Forkhead box protein P3
Weight
47.346kDa
Alternative Names
AIID; AIIDMGC141961; human foxp3; mouse foxp3; DIETER; forkhead box P3; Forkhead Box Protein P3; foxp3 ihc; foxp3 paraffin; FoxP3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked; IPEX; JM2; MGC141961; MGC141963; PIDX; PIDXMGC141963; SCURFIN; XPID; XPIDpolyendocrinopathy, enteropathy, X-linked Foxp3|JM2, scu, scurfin, sf|forkhead box P3|forkhead box protein P3|scurfy
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Foxp3, check out the Foxp3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Foxp3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Forkhead box protein P3 FOXP3 Antibody (A00011-1)
Hello CJ!
A00011-1 has been cited in 5 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
IL-35 improves Treg-mediated immune suppression in atherosclerotic mice
Decreased FOXP3+ and GARP+ Tregs to neoadjuvant chemotherapy associated with favorable prognosis in advanced gastric cancer
Wang B, Dai S, Dong Z, Sun Y, Song X, Guo C, Zhu F, Wang Q, Zhang L. Plos One. 2014 Jan 30;9(1):E87787. Doi: 10.1371/Journal.Pone.0087787. Ecollection 2014. The Modulation Of Endoplasmic Reticulum Stress By Chemical Chaperone Upregulates Immune Ne...
Hu M, Li K, Maskey N, Xu Z, Peng C, Wang B, Li Y, Yang G. Int J Clin Exp Pathol. 2014 Jul 15;7(8):4685-94. Ecollection 2014. Decreased Intratumoral Foxp3 Tregs And Increased Dendritic Cell Density By Neoadjuvant Chemotherapy Associated With Favora...
Gong T, Wang Cf, Yuan Jr, Li Y, Gu Jf, Zhao Bj, Zhang L, Jia Xb, Feng L, Liu Sl. Evid Based Complement Alternat Med. 2015;2015:630760. Doi: 10.1155/2015/630760. Epub 2015 May 3. Inhibition Of Tumor Growth And Immunomodulatory Effects Of Flavonoids...
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