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Product Info Summary
|Reactive Species:||Human, Mouse, Rat|
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Boster Bio Anti-Grik2 Antibody (Catalog # A03374-1). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Grik2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Grik2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03374-1)
Grik2 Antibody is supplied in PBS containing 0.02% sodium azide.
Grik2 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human Grik2. The immunogen is located within the last 50 amino acids of Grik2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
A03374-1 is reactive to GRIK2 in Human, Mouse, Rat
A03374-1 is guaranteed for ELISA, WB Boster Guarantee
Background of Glutamate Receptor 6
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik2, also known as glutamate receptor 6, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Recent reports have suggested that defects in the Grik2 protein may be associated with autosomal recessive mental retardation and possibly other neurological disorders such as schizophrenia. Numerous isoforms of Grik2 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow. This Grik2 antibody may exhibit some cross-reactivity to Grik3.
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence and ELISA with known positive and negative samples to ensure specificity and high affinity.
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Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. Actual working concentration varies and should be decided by the user.
Grik2 antibody can be used for detection of Grik2 by Western blot at 0.5 - 1 μg/mL. Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Validation Images & Assay Conditions
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Western blot analysis of Grik2 in human brain tissue lysate with Grik2 antibody at (A) 0.5 and (B) 1 μg/mL.
Gene/Protein Information For GRIK2 (Source: Uniprot.org, NCBI)
Glutamate receptor ionotropic, kainate 2
glutamate-gated ion channel (TC 1.A.10.1) family
EAA4; glutamate receptor 6; glutamate receptor, ionotropic, kainate 2; ionotropic kainate 2; MGC74427 GRIK2 EAA4, GLR6, GLUK6, GLUR6, GluK2, MRT6 glutamate ionotropic receptor kainate type subunit 2 glutamate receptor ionotropic, kainate 2|bA487F5.1|excitatory amino acid receptor 4|gluR-6|glutamate receptor 6|glutamate receptor form A|glutamate receptor form B|glutamate receptor form C|glutamate receptor form D|glutamate receptor form E*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".
For more info on GRIK2, check out the GRIK2 Infographic
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In this infographic, you will see the following information for GRIK2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected]
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