Anti-Grik3 Antibody

Product Name

Anti-Grik3 Antibody

View all GluR7/GRIK3 Antibodies

SKU/Catalog Number

A06927

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Grik3 Antibody (Catalog # A06927). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Grik3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-Grik3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06927)

Host

Rabbit

Contents

Grik3 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Grik3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of the human Grik3. The immunogen is located within amino acids 30 - 80 of Grik3.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least three isoforms of EVER2 are known to exist; this antibody will only recognize the larger isoform. EVER2 has no cross-reactivity to EVER1.

Reactive Species

A06927 is reactive to GRIK3 in Human, Mouse, Rat

Applications

A06927 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

104.037kDa

Background of GluR7/GRIK3

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia. This Grik3 antibody does not cross-react with Grik2.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Grik3 antibody can be used for detection of Grik3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of Grik3 in human brain tissue lysate with Grik3 antibody at (A) 1 and (B) 2 μg/mL.

Gene/Protein Information For GRIK3 (Source: Uniprot.org, NCBI)

Alternative Names

EAA5; Excitatory amino acid receptor 5; GLR7; GluK3; GluR7; gluR-7; GluR7a; GLUR7dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)); Glutamate receptor 7; glutamate receptor, ionotropic kainate 3; glutamate receptor, ionotropic, kainate 3; GRIK3 GRIK3 EAA5, GLR7, GLUR7, GluK3, GluR7a glutamate ionotropic receptor kainate type subunit 3 glutamate receptor ionotropic, kainate 3|dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))|excitatory amino acid receptor 5|gluR-7|glutamate receptor 7

For more info on GRIK3, check out the GRIK3 Infographic

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In this infographic, you will see the following information for GRIK3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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