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Product Info Summary
| SKU: | A03623 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | IF, WB |
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Product info
Product Name
Anti-GRK6 Antibody
SKU/Catalog Number
A03623
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-GRK6 Antibody (Catalog # A03623). Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-GRK6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03623)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from N-terminal of human GRK6.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A03623 is reactive to GRK6 in Human, Mouse, Rat
Applications
A03623 is guaranteed for IF, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
65.991kDa
Background of GRK6
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis By similarity. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Benovic J.L., J. Biol. Chem. 268:19521-19527(1993).
Haribabu B., Proc. Natl. Acad. Sci. U.S.A. 90:9398-9402(1993).
Stoffel R.H., J. Biol. Chem. 269:27791-27794(1994).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1:500~1:3000
Immunofluorescence: 1:100~1:500
Validation Images & Assay Conditions
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Western blot analysis of extracts from Jurkat cells, COLO205 cells and HUVEC cells, using GRK6 antibody A03623.
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Immunofluorescence analysis of HeLa cells, using GRK6 antibody A03623.
Protein Target Info & Infographic
Gene/Protein Information For GRK6 (Source: Uniprot.org, NCBI)
Gene Name
GRK6
Full Name
G protein-coupled receptor kinase 6
Weight
65.991kDa
Superfamily
protein kinase superfamily
Alternative Names
EC 2.7.11; EC 2.7.11.16; FLJ32135; G protein-coupled receptor kinase 6; GPRK6G protein-coupled receptor kinase GRK6 GRK6 GPRK6 G protein-coupled receptor kinase 6 G protein-coupled receptor kinase 6
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GRK6, check out the GRK6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GRK6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-GRK6 Antibody (A03623)
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No publications found for A03623
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Customer Reviews
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