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Product Info Summary
| SKU: | A05242-1 |
|---|---|
| Size: | 100ul |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | IF, IHC |
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Product info
Product Name
Anti-HisRS (E492) HARS Antibody
SKU/Catalog Number
A05242-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-HisRS (E492) HARS Antibody catalog # A05242-1. Tested in IHC,IF applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-HisRS (E492) HARS Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05242-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from C-terminal of human HARS.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A05242-1 is reactive to HARS1 in Human, Mouse, Rat
Applications
A05242-1 is guaranteed for IF, IHC Boster Guarantee
Observed Molecular Weight
111 kDa
Calculated molecular weight
57.411kDa
Background of HARS1
Defects in HARS are a cause of Usher syndrome type 3B (USH3B). USH3B is a syndrome characterized by progressive vision and hearing loss during early childhood. Some patients have the so-called 'Charles Bonnet syndrome,' involving decreased visual acuity and vivid visual hallucinations. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH3 is characterized by postlingual, progressive hearing loss, variable vestibular dysfunction, and onset of retinitis pigmentosa symptoms, including nyctalopia, constriction of the visual fields, and loss of central visual acuity, usually by the second decade of life. Belongs to the class-II aminoacyl-tRNA synthetase family.
Raben N., Nucleic Acids Res. 20:1075-1081(1992).
Tsui F.W.L., Nucleic Acids Res. 15:3349-3367(1987).
Tsui H.W., Gene 131:201-208(1993).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
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Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IHC: 1:50-1:200
IF: 1:50-1:200
Validation Images & Assay Conditions
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Figure 1. Immunohistochemistry validation of HARS using Anti-HisRS (E492) HARS Antibody (A05242-1).
Immunohistochemistry (IHC) analyzes of HisRS (E492) pAb in paraffin-embedded human brain carcinoma tissue at 1:50.For more protocol information of IHC
Protein Target Info & Infographic
Gene/Protein Information For HARS1 (Source: Uniprot.org, NCBI)
Gene Name
HARS1
Full Name
Histidine--tRNA ligase, cytoplasmic
Weight
57.411kDa
Superfamily
class-II aminoacyl-tRNA synthetase family
Alternative Names
Histidine--tRNA ligase, cytoplasmic HARS1 CMT2W, HARS, HRS, USH3B histidyl-tRNA synthetase 1 histidine--tRNA ligase, cytoplasmic|HisRS|Jo-1 antigen|histidine translase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on HARS1, check out the HARS1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for HARS1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-HisRS (E492) HARS Antibody (A05242-1)
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No publications found for A05242-1
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Customer Reviews
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